Expression analysis for inverted effects of serotonin transporter inactivation
- Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 (Japan)
- Computational Biomechanics Unit, Discovery Research Institute, RIKEN, 2-1 Hirosawa Wako City, Saitama 351-0198 (Japan)
- Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Univ. of Wuerzburg Fuechsleinstr. 15, 97080 Wuerzburg (Germany)
- Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Inst., 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045 (Japan)
Inactivation of serotonin transporter (HTT) by pharmacologically in the neonate or genetically increases risk for depression in adulthood, whereas pharmacological inhibition of HTT ameliorates symptoms in depressed patients. The differing role of HTT function during early development and in adult brain plasticity in causing or reversing depression remains an unexplained paradox. To address this we profiled the gene expression of adult Htt knockout (Htt KO) mice and HTT inhibitor-treated mice. Inverted profile changes between the two experimental conditions were seen in 30 genes. Consistent results of the upstream regulatory element search and the co-localization search of these genes indicated that the regulation may be executed by Pax5, Pax7 and Gata3, known to be involved in the survival, proliferation, and migration of serotonergic neurons in the developing brain, and these factors are supposed to keep functioning to regulate downstream genes related to serotonin system in the adult brain.
- OSTI ID:
- 21043670
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 368, Issue 1; Other Information: DOI: 10.1016/j.bbrc.2008.01.041; PII: S0006-291X(08)00062-4; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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