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Title: SU11657 Enhances Radiosensitivity of Human Meningioma Cells

Abstract

Purpose: To analyze the effect of the multireceptor tyrosine kinase inhibitor SU11657 (primarily vascular endothelial growth factor, platelet-derived growth factor) in combination with irradiation in freshly isolated primary human meningioma cells. Methods and Materials: Tumor specimens were obtained from meningioma patients undergoing surgery at the Department of Neurosurgery, University of Heidelberg, Germany. For the present study only cells up to passage 6 were used. Benign and atypical meningioma cells and human umbilical vein endothelial cells (HUVEC) were treated with SU11657 alone and in combination with 6-MV photons (0-10 Gy). Clonogenic survival and cell proliferation were determined alone and in coculture assays to determine direct and paracrine effects. Results: Radiation and SU11657 alone reduced cell proliferation in atypical and benign meningioma cells as well as in HUVEC in a dose-dependent manner. SU11657 alone also reduced clonogenic survival of benign and atypical meningioma cells. SU11657 increased radiosensitivity of human meningioma cells in clonogenic survival and cell number/proliferation assays. The anticlonogenic and antiproliferative effects alone and the radiosensitization effects of SU11657 were more pronounced in atypical meningioma cells compared with benign meningioma cells. Conclusion: Small-molecule tyrosine kinase inhibitors like SU11657 are capable of amplifying the growth inhibitory effects of irradiation in meningioma cells.more » These data provide a rationale for further clinical evaluation of this combination concept, especially in atypical and malignant meningioma patients.« less

Authors:
 [1];  [1];  [2];  [1];  [2];  [1];  [3]; ;  [1]
  1. Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)
  2. Department of Neurosurgery, University of Heidelberg, Heidelberg (Germany)
  3. 3M Pharmaceuticals, St. Paul, MN (United States)
Publication Date:
OSTI Identifier:
21039846
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 70; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2007.11.041; PII: S0360-3016(07)04590-7; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CELL PROLIFERATION; EVALUATION; GROWTH FACTORS; IRRADIATION; NEOPLASMS; PATIENTS; RADIOSENSITIVITY; RADIOTHERAPY; RECEPTORS; SURGERY; TYROSINE; VEINS

Citation Formats

Milker-Zabel, Stefanie, Bois, Angelika Zabel-du, Ranai, Gholamreza, Trinh, Thuy, Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Unterberg, Andreas, Debus, Juergen, Lipson, Kenneth E, Abdollahi, Amir, Huber, Peter E, and Department of Radiation Oncology, German Cancer Research Center, Heidelberg. SU11657 Enhances Radiosensitivity of Human Meningioma Cells. United States: N. p., 2008. Web. doi:10.1016/j.ijrobp.2007.11.041.
Milker-Zabel, Stefanie, Bois, Angelika Zabel-du, Ranai, Gholamreza, Trinh, Thuy, Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Unterberg, Andreas, Debus, Juergen, Lipson, Kenneth E, Abdollahi, Amir, Huber, Peter E, & Department of Radiation Oncology, German Cancer Research Center, Heidelberg. SU11657 Enhances Radiosensitivity of Human Meningioma Cells. United States. https://doi.org/10.1016/j.ijrobp.2007.11.041
Milker-Zabel, Stefanie, Bois, Angelika Zabel-du, Ranai, Gholamreza, Trinh, Thuy, Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Unterberg, Andreas, Debus, Juergen, Lipson, Kenneth E, Abdollahi, Amir, Huber, Peter E, and Department of Radiation Oncology, German Cancer Research Center, Heidelberg. 2008. "SU11657 Enhances Radiosensitivity of Human Meningioma Cells". United States. https://doi.org/10.1016/j.ijrobp.2007.11.041.
@article{osti_21039846,
title = {SU11657 Enhances Radiosensitivity of Human Meningioma Cells},
author = {Milker-Zabel, Stefanie and Bois, Angelika Zabel-du and Ranai, Gholamreza and Trinh, Thuy and Department of Radiation Oncology, German Cancer Research Center, Heidelberg and Unterberg, Andreas and Debus, Juergen and Lipson, Kenneth E and Abdollahi, Amir and Huber, Peter E and Department of Radiation Oncology, German Cancer Research Center, Heidelberg},
abstractNote = {Purpose: To analyze the effect of the multireceptor tyrosine kinase inhibitor SU11657 (primarily vascular endothelial growth factor, platelet-derived growth factor) in combination with irradiation in freshly isolated primary human meningioma cells. Methods and Materials: Tumor specimens were obtained from meningioma patients undergoing surgery at the Department of Neurosurgery, University of Heidelberg, Germany. For the present study only cells up to passage 6 were used. Benign and atypical meningioma cells and human umbilical vein endothelial cells (HUVEC) were treated with SU11657 alone and in combination with 6-MV photons (0-10 Gy). Clonogenic survival and cell proliferation were determined alone and in coculture assays to determine direct and paracrine effects. Results: Radiation and SU11657 alone reduced cell proliferation in atypical and benign meningioma cells as well as in HUVEC in a dose-dependent manner. SU11657 alone also reduced clonogenic survival of benign and atypical meningioma cells. SU11657 increased radiosensitivity of human meningioma cells in clonogenic survival and cell number/proliferation assays. The anticlonogenic and antiproliferative effects alone and the radiosensitization effects of SU11657 were more pronounced in atypical meningioma cells compared with benign meningioma cells. Conclusion: Small-molecule tyrosine kinase inhibitors like SU11657 are capable of amplifying the growth inhibitory effects of irradiation in meningioma cells. These data provide a rationale for further clinical evaluation of this combination concept, especially in atypical and malignant meningioma patients.},
doi = {10.1016/j.ijrobp.2007.11.041},
url = {https://www.osti.gov/biblio/21039846}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 70,
place = {United States},
year = {Sat Mar 15 00:00:00 EDT 2008},
month = {Sat Mar 15 00:00:00 EDT 2008}
}