Phyllodes Tumor of the Breast

Journal Article · Fri Feb 01 00:00:00 EST 2008 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2007.06.059· OSTI ID:21039760

Belkacemi, Yazid ^[1]; Bousquet, Guilhem ^[2]; Marsiglia, Hugo ^[3]; Ray-Coquard, Isabelle ^[4]; Magne, Nicolas ^[5]; Malard, Yann ^[6]; Lacroix, Magalie ^[7]; Gutierrez, Cristina ^[8]; Senkus, Elzbieta ^[9]; Christie, David ^[10]; Drumea, Karen ^[11]; Lagneau, Edouard ^[12]; Kadish, Sidney P ^[13]; Scandolaro, Luciano ^[14]; Azria, David ^[15]; Ozsahin, Mahmut ^[16]

---

1. Centre Oscar Lambret, Lille (France)
2. University of Lille II, Lille (France)
3. Institut Gustave Roussy, Villejuif (France)
4. CRLC Leon Berard, Lyon (France)
5. Institut Jules Bordet, Brussels (Belgium)
6. CRLC F. Bergonie, Bordeaux (France)
7. CRLC Claudius Regaud, Toulouse (France)
8. Institut Catala d'Oncologia, L'Hospitalet (Spain)
9. Medical University, Gdansk (Poland)
10. East Coast Cancer Center, Tugun, Queensland (Australia)
11. Rambam Medical Center, Haifa (Israel)
12. CHU, Besancon (France)
13. University of Massachusetts, North Worcester, MA (United States)
14. Divisione di Radioterapia Oncologica, Ospedale S. Anna, Como (Italy)
15. CRLC Val d'Aurelle, Montpellier (France)
16. Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

Purpose: To better identify prognostic factors for local control and survival, as well as the role of different therapeutic options, for phyllodes tumors, a rare fibroepithelial neoplasm of the breast. Methods and Materials: Data from 443 women treated between 1971 and 2003 were collected from the Rare Cancer Network. The median age was 40 years (range, 12-87 years). Tumors were benign in 284 cases (64%), borderline in 80 cases (18%), and malignant in 79 cases (18%). Surgery consisted of breast-conserving surgery (BCS) in 377 cases (85%) and total mastectomy (TM) in 66 cases (15%). Thirty-nine patients (9%) received adjuvant radiotherapy (RT). Results: After a median follow-up of 106 months, local recurrence (LR) and distant metastases rates were 19% and 3.4%, respectively. In the malignant and borderline group (n = 159), RT significantly decreased LR (p = 0.02), and TM had better results than BCS (p = 0.0019). Multivariate analysis revealed benign histology, negative margins, and no residual disease (no RD) after initial treatment and RT delivery as independent favorable prognostic factors for local control; benign histology and low number of mitosis for disease-free survival; and pathologic tumor size </= 3 cm and no tumor necrosis for overall survival. In the malignant and borderline subgroup multivariate analysis TM was the only favorable independent prognostic factor for disease-free survival. Conclusions: This study showed that phyllodes tumor patients with no RD after treatment have better local control. Benign tumors have a good prognosis after surgery alone. In borderline and malignant tumors, TM had better results than BCS. Thus, in these forms adjuvant RT should be considered according to histologic criteria.

• OSTI ID: 21039760
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 70, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2007.06.059; PII: S0360-3016(07)01175-3; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
HISTOLOGY
MAMMARY GLANDS
METASTASES
MITOSIS
MULTIVARIATE ANALYSIS
PATIENTS
RADIOTHERAPY
SURGERY
WOMEN