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Title: Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract

Abstract

Purpose: To investigate the role of early or up-front radiotherapy (RT), the optimal RT dose required to achieve appropriate treatment outcome and prognostic factors for patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract. Methods and Materials: Eighty-two patients were reviewed. Eight patients were treated with chemotherapy (CT) alone, 9 patients received RT alone, and 65 patients were given combined modality treatment of CT and RT (CMT). Of those 74 patients receiving RT, 31 patients were given up-front RT, whereas CT was the initial therapy for 43 patients and 41 of those 43 patients received early RT. Results: Five-year overall survival (OS) and disease-free survival (DFS) were 52.3% and 39.2%, respectively. RT was the only independent prognostic factor for both OS and DFS at both the univariate and multivariate level. The 5-year OS and DFS were better in patients receiving {>=}54 Gy of RT as compared with that of <54 Gy (5-year OS 75.5% vs. 46.1%, p = 0.019; 5-year DFS 60.3% vs. 33.4%, p = 0.004). Up-front RT presented better survival in Stage I patients when compared with that of initial CT followed by early RT (5-year OS 90.0% vs. 48.9%, p = 0.012; 5-year DFSmore » 78.7% vs. 39.9%, p = 0.021). Conclusion: Early or up-front RT had an essential role in improved OS and DFS in patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract. The recommended tumor dose was at least 54 Gy. Up-front RT may yield more benefits on survival in patients with Stage I disease.« less

Authors:
;  [1];  [2];  [3]; ;  [1];  [3];  [1]; ; ; ;  [1];  [1]
  1. Department of Biotherapy for Cancer, West China Hospital, Medical School, Sichuan University, Chengdu (China)
  2. Department of Pathology, West China Hospital, Medical School, Sichuan University, Chengdu (China)
  3. Department of Radiotherapy for Cancer, West China Hospital, Medical School, Sichuan University, Chengdu (China)
Publication Date:
OSTI Identifier:
21039715
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 70; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2007.05.073; PII: S0360-3016(07)01030-9; Copyright (c) 2008 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; LYMPHOMAS; MULTIVARIATE ANALYSIS; NOSE; PATIENTS; RADIATION DOSES; RADIOTHERAPY

Citation Formats

Meijuan, Huang, Yu, Jiang, State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu, Weiping, Liu, Zhiping, Li, Mei, Li, Lin, Zhou, Yong, Xu, Chunhua, Yu, Qiu, Li, Feng, Peng, Jiyan, Liu, Feng, Luo, State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu, You, Lu, and State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu. Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract. United States: N. p., 2008. Web. doi:10.1016/j.ijrobp.2007.05.073.
Meijuan, Huang, Yu, Jiang, State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu, Weiping, Liu, Zhiping, Li, Mei, Li, Lin, Zhou, Yong, Xu, Chunhua, Yu, Qiu, Li, Feng, Peng, Jiyan, Liu, Feng, Luo, State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu, You, Lu, & State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu. Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract. United States. https://doi.org/10.1016/j.ijrobp.2007.05.073
Meijuan, Huang, Yu, Jiang, State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu, Weiping, Liu, Zhiping, Li, Mei, Li, Lin, Zhou, Yong, Xu, Chunhua, Yu, Qiu, Li, Feng, Peng, Jiyan, Liu, Feng, Luo, State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu, You, Lu, and State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu. 2008. "Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract". United States. https://doi.org/10.1016/j.ijrobp.2007.05.073.
@article{osti_21039715,
title = {Early or Up-Front Radiotherapy Improved Survival of Localized Extranodal NK/T-Cell Lymphoma, Nasal-Type in the Upper Aerodigestive Tract},
author = {Meijuan, Huang and Yu, Jiang and State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu and Weiping, Liu and Zhiping, Li and Mei, Li and Lin, Zhou and Yong, Xu and Chunhua, Yu and Qiu, Li and Feng, Peng and Jiyan, Liu and Feng, Luo and State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu and You, Lu and State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu},
abstractNote = {Purpose: To investigate the role of early or up-front radiotherapy (RT), the optimal RT dose required to achieve appropriate treatment outcome and prognostic factors for patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract. Methods and Materials: Eighty-two patients were reviewed. Eight patients were treated with chemotherapy (CT) alone, 9 patients received RT alone, and 65 patients were given combined modality treatment of CT and RT (CMT). Of those 74 patients receiving RT, 31 patients were given up-front RT, whereas CT was the initial therapy for 43 patients and 41 of those 43 patients received early RT. Results: Five-year overall survival (OS) and disease-free survival (DFS) were 52.3% and 39.2%, respectively. RT was the only independent prognostic factor for both OS and DFS at both the univariate and multivariate level. The 5-year OS and DFS were better in patients receiving {>=}54 Gy of RT as compared with that of <54 Gy (5-year OS 75.5% vs. 46.1%, p = 0.019; 5-year DFS 60.3% vs. 33.4%, p = 0.004). Up-front RT presented better survival in Stage I patients when compared with that of initial CT followed by early RT (5-year OS 90.0% vs. 48.9%, p = 0.012; 5-year DFS 78.7% vs. 39.9%, p = 0.021). Conclusion: Early or up-front RT had an essential role in improved OS and DFS in patients with localized extranodal NK/T-cell lymphoma, nasal-type, in the upper aerodigestive tract. The recommended tumor dose was at least 54 Gy. Up-front RT may yield more benefits on survival in patients with Stage I disease.},
doi = {10.1016/j.ijrobp.2007.05.073},
url = {https://www.osti.gov/biblio/21039715}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 1,
volume = 70,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2008},
month = {Tue Jan 01 00:00:00 EST 2008}
}