Contrast-Enhanced Digital Mammography and Angiogenesis
- Instituto de Fisica, Universidad Nacional Autonoma de Mexico (Mexico)
- Instituto Nacional de Cancerologia (INCan) (Mexico)
- Centro Medico Nacional Siglo XXI (Mexico)
Angiogenesis could be a means for pouring contrast media around tumors. In this work, optimization of radiological parameters for contrast-enhanced subtraction techniques in mammography has been performed. A modification of Lemacks' analytical formalism was implemented to model the X-ray absorption in the breast with contrast medium and detection by a digital image receptor. Preliminary results of signal-to-noise ratio analysis show the advantage of subtracting two images taken at different energies, one prior and one posterior to the injection of contrast medium. Preliminary experimental results using a custom-made phantom have shown good agreement with calculations. A proposal is presented for the clinical application of the optimized technique, which aims at finding correlations between angiogenesis indicators and dynamic variables of contrast medium uptake.
- OSTI ID:
- 21039416
- Journal Information:
- AIP Conference Proceedings, Vol. 958, Issue 1; Conference: 4. International summer school on nuclear physics methods and accelerators in biology and medicine, Prague (Czech Republic), 8-19 Jul 2007; Other Information: DOI: 10.1063/1.2825815; (c) 2007 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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