SNP analyses of growth factor genes EGF, TGF{beta}-1, and HGF reveal haplotypic association of EGF with autism

Journal Article · Fri Sep 07 00:00:00 EDT 2007 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2007.06.051· OSTI ID:20991519

Toyoda, Takao; Thanseem, Ismail; Kawai, Masayoshi; Sekine, Yoshimoto ^[1]; Nakamura, Kazuhiko; Anitha, Ayyappan; Suda, Shiro ^[1]; Yamada, Kazuo ^[2]; Tsujii, Masatsugu ^[3]; Iwayama, Yoshimi; Hattori, Eiji; Toyota, Tomoko; Yoshikawa, Takeo ^[2]; Miyachi, Taishi; Tsuchiya, Kenji; Sugihara, Gen-ichi; Matsuzaki, Hideo ^[4]; Iwata, Yasuhide; Suzuki, Katsuaki ^[1]; Mori, Norio ^[1] ; Ouchi, Yasuomi ^[4]; Sugiyama, Toshiro ^[5]; Takei, Nori ^[4]

---

1. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431-3192 (Japan)
2. Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama (Japan)
3. Faculty of Sociology, Chukyo University, Toyota, Aichi (Japan)
4. The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu (Japan)
5. Aichi Children's Health and Medical Center, Obu, Aichi (Japan)

Autism is a pervasive neurodevelopmental disorder diagnosed in early childhood. Growth factors have been found to play a key role in the cellular differentiation and proliferation of the central and peripheral nervous systems. Epidermal growth factor (EGF) is detected in several regions of the developing and adult brain, where, it enhances the differentiation, maturation, and survival of a variety of neurons. Transforming growth factor-{beta} (TGF{beta}) isoforms play an important role in neuronal survival, and the hepatocyte growth factor (HGF) has been shown to exhibit neurotrophic activity. We examined the association of EGF, TGF{beta}1, and HGF genes with autism, in a trio association study, using DNA samples from families recruited to the Autism Genetic Resource Exchange; 252 trios with a male offspring scored for autism were selected for the study. Transmission disequilibrium test revealed significant haplotypic association of EGF with autism. No significant SNP or haplotypic associations were observed for TGF{beta}1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism.

• OSTI ID: 20991519
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 360, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2007.06.051; PII: S0006-291X(07)01255-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
CELL PROLIFERATION
DNA
GENES
GROWTH FACTORS
MATURATION
NERVE CELLS
PATHOGENESIS
PROGENY