The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases
- Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029 (China)
Growing cell-based myocardial therapies which could lead to successful myocardial repair attracts medical interest. Even more intriguing is the observation that MSCs appears to be a more potent material among kinds of stem cells for the transplantation, the mechanism for this benefit remains unclear. However, the therapeutic contribution of MSCs to myocardial repair can be caused by multiple factors including: direct differentiation into cardiac tissue including cardiomyocytes, smooth muscle cell, and vascular endothelial cells; secreting a variety of cytokines and growth factors that have paracrine activities; spontaneous cell fusion; and stimulating endogenous repair. In addition, MSCs possess local immunosuppressive properties, and MSCs mobilization is widely used clinically for transplantation. We will discusses the potential mechanisms of MSCs repair for ischemic heart diseases.
- OSTI ID:
- 20991451
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 359, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2007.05.112; PII: S0006-291X(07)01086-8; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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