Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-{gamma} activation

Journal Article · Fri May 18 00:00:00 EDT 2007 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2007.03.084· OSTI ID:20991349

Moriuchi, Akie ^[1]; Yamasaki, Hironori ^[1]; Shimamura, Mika ^[2]; Kita, Atsushi; Kuwahara, Hironaga; Satoh, Tsuyoshi; Satoh, Tsuyoshi ^[1]; Fujishima, Keiichiro; Fukushima, Keiko ^[1]; Fukushima, Tetsuya; Abiru, Norio; Eguchi, Katsumi ^[1]; Hayakawa, Takao; Mizuguchi, Hiroyuki ^[3]; Nagayama, Yuji ^[4]; Kawasaki, Eiji ^[5]

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1. Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University (Japan)
2. Course of Pharmaceutical Sciences, Graduate School of Biomedical Science, Nagasaki University (Japan)
3. Project III, National Institute of Health Sciences, Osaka Branch, Fundamental Research Laboratories for Development of Medicine (Japan)
4. Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biochemical Sciences, Nagasaki University (Japan)
5. Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University, Hospital of Medicine and Dentistry, Nagasaki (Japan)

Adiponectin, an adipose tissue-specific plasma protein, has been shown to ameliorate insulin resistance and inhibit the process of atherosclerosis. Recently, several reports have stated that angiotensin type 1 receptor blockers (ARBs), increase adiponectin plasma level, and ameliorate insulin resistance. Telmisartan, a subclass of ARBs, has been shown to be a partial agonist of the peroxisome proliferator-activated receptor (PPAR)-{gamma}, and to increase the plasma adiponectin level. However, the transcriptional regulation of the human adiponectin gene by telmisartan has not been determined yet. To elucidate the effect of telmisartan on adiponectin, the stimulatory regulation of human adiponectin gene by telmisartan was investigated in 3T3-L1 adipocytes, utilizing adenovirus-mediated luciferase reporter gene-transferring technique. This study indicates that telmisartan may stimulate adiponectin transcription independent of PPAR-{gamma}.

• OSTI ID: 20991349
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 356, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2007.03.084; PII: S0006-291X(07)00579-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ADIPOSE TISSUE
ANGIOTENSIN
ARTERIOSCLEROSIS
GENES
INSULIN
LUCIFERASE
RECEPTORS
TRANSCRIPTION