skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: High diversity of {alpha}-globin haplotypes in a senegalese population, including many previously unreported variants

Abstract

RFLP haplotypes at the {alpha}-globin gene complex have been examined in 190 individuals from the Niokolo Mandenka population of Senegal: haplotypes were assigned unambiguously for 210 chromosomes. The Mandenka share with other African populations a sample size-independent haplotype diversity that is much greater than that in any non-African population: the number of haplotypes observed in the Mandenka is typically twice that seen in the non-African populations sampled to date. Of these haplotypes, 17.3% had not been observed in any previous surveys, and a further 19.1% have previously been reported only in African populations. The haplotype distribution shows clear differences between African and non-African peoples, but this is on the basis of population-specific haplotypes combined with haplotypes common to all. The relationship of the newly reported haplotypes to those previously recorded suggests that several mutation processes, particularly recombination as homologous exchange or gene conversion, have been involved in their production. A computer program based on the expectation-maximization (EM) algorithm was used to obtain maximum-likelihood estimates of haplotype frequencies for the entire data set: good concordance between the unambiguous and EM-derived sets was seen for the overall haplotype frequencies. Some of the low-frequency haplotypes reported by the estimation algorithm differ greatly, inmore » structure, from those haplotypes known to be present in human populations, and they may not represent haplotypes actually present in the sample. 43 refs., 4 figs., 4 tabs.« less

Authors:
; ;  [1]
  1. and others
Publication Date:
OSTI Identifier:
209913
Resource Type:
Journal Article
Journal Name:
American Journal of Human Genetics
Additional Journal Information:
Journal Volume: 57; Journal Issue: 5; Other Information: PBD: Nov 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN POPULATIONS; GENETIC VARIABILITY; GENES; GENE RECOMBINATION; GENE MUTATIONS; GENETICS; COMPUTER CODES; ALGORITHMS; SENEGAL; HUMAN CHROMOSOMES; RFLPS; STATISTICS

Citation Formats

Martinson, J J, Swinburn, C, and Clegg, J B. High diversity of {alpha}-globin haplotypes in a senegalese population, including many previously unreported variants. United States: N. p., 1995. Web.
Martinson, J J, Swinburn, C, & Clegg, J B. High diversity of {alpha}-globin haplotypes in a senegalese population, including many previously unreported variants. United States.
Martinson, J J, Swinburn, C, and Clegg, J B. 1995. "High diversity of {alpha}-globin haplotypes in a senegalese population, including many previously unreported variants". United States.
@article{osti_209913,
title = {High diversity of {alpha}-globin haplotypes in a senegalese population, including many previously unreported variants},
author = {Martinson, J J and Swinburn, C and Clegg, J B},
abstractNote = {RFLP haplotypes at the {alpha}-globin gene complex have been examined in 190 individuals from the Niokolo Mandenka population of Senegal: haplotypes were assigned unambiguously for 210 chromosomes. The Mandenka share with other African populations a sample size-independent haplotype diversity that is much greater than that in any non-African population: the number of haplotypes observed in the Mandenka is typically twice that seen in the non-African populations sampled to date. Of these haplotypes, 17.3% had not been observed in any previous surveys, and a further 19.1% have previously been reported only in African populations. The haplotype distribution shows clear differences between African and non-African peoples, but this is on the basis of population-specific haplotypes combined with haplotypes common to all. The relationship of the newly reported haplotypes to those previously recorded suggests that several mutation processes, particularly recombination as homologous exchange or gene conversion, have been involved in their production. A computer program based on the expectation-maximization (EM) algorithm was used to obtain maximum-likelihood estimates of haplotype frequencies for the entire data set: good concordance between the unambiguous and EM-derived sets was seen for the overall haplotype frequencies. Some of the low-frequency haplotypes reported by the estimation algorithm differ greatly, in structure, from those haplotypes known to be present in human populations, and they may not represent haplotypes actually present in the sample. 43 refs., 4 figs., 4 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/209913}, journal = {American Journal of Human Genetics},
number = 5,
volume = 57,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 1995},
month = {Wed Nov 01 00:00:00 EST 1995}
}