Inorganic arsenic exposure and type 2 diabetes mellitus in Mexico
- Clinical Epidemiologic Research Unit, General Regional Hospital 1 'Gabriel Mancera', Mexican Institute of the Social Security, Mexico, D.F. (Mexico)
- Toxicology Departament, Cinvestav, Mexico D.F. (Mexico)
- School of Medicine, Durango State Juarez University, Gomez Palacio, Durango (Mexico)
- Biomedical Research Center, Coahuila, Autonomous University, Torreon, Coahuila (Mexico)
Inorganic arsenic exposure in drinking water has been recently related to diabetes mellitus. To evaluate this relationship the authors conducted in 2003, a case-control study in an arseniasis-endemic region from Coahuila, a northern state of Mexico with a high incidence of diabetes. The present analysis includes 200 cases and 200 controls. Cases were obtained from a previous cross-sectional study conducted in that region. Diagnosis of diabetes was established following the American Diabetes Association criteria, with two fasting glucose values {>=}126 mg/100 ml ({>=}7.0 mmol/l) or a history of diabetes treated with insulin or oral hypoglycemic agents. The next subject studied, subsequent to the identification of a case in the cross-sectional study was taken as control. Inorganic arsenic exposure was measured through total arsenic concentrations in urine, measured by hydride-generation atomic absorption spectrophotometry. Subjects with intermediate total arsenic concentration in urine (63.5-104 {mu}g/g creatinine) had two-fold higher risk of having diabetes (odds ratio=2.16; 95% confidence interval: 1.23, 3.79), but the risk was almost three times greater in subjects with higher concentrations of total arsenic in urine (odds ratio=2.84; 95% confidence interval: 1.64, 4.92). This data provides additional evidence that inorganic arsenic exposure may be diabetogenic.
- OSTI ID:
- 20972077
- Journal Information:
- Environmental Research, Vol. 104, Issue 3; Other Information: DOI: 10.1016/j.envres.2007.03.004; PII: S0013-9351(07)00074-6; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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