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Title: A Prospective Evaluation of Helical Tomotherapy

Abstract

Purpose: To report results from two clinical trials evaluating helical tomotherapy (HT). Methods and Materials: Patients were enrolled in one of two prospective trials of HT (one for palliative and one for radical treatment). Both an HT plan and a companion three-dimensional conformal radiotherapy (3D-CRT) plan were generated. Pretreatment megavoltage computed tomography was used for daily image guidance. Results: From September 2004 to January 2006, a total of 61 sites in 60 patients were treated. In all but one case, a clinically acceptable tomotherapy plan for treatment was generated. Helical tomotherapy plans were subjectively equivalent or superior to 3D-CRT in 95% of plans. Helical tomotherapy was deemed equivalent or superior in two thirds of dose-volume point comparisons. In cases of inferiority, differences were either clinically insignificant and/or reflected deliberate tradeoffs to optimize the HT plan. Overall imaging and treatment time (median) was 27 min (range, 16-91 min). According to a patient questionnaire, 78% of patients were satisfied to very satisfied with the treatment process. Conclusions: Helical tomotherapy demonstrated clear advantages over conventional 3D-CRT in this diverse patient group. The prospective trials were helpful in deploying this technology in a busy clinical setting.

Authors:
 [1];  [1];  [1]; ; ; ;  [1]; ; ; ;  [1]; ; ; ;  [1];  [2]
  1. London Regional Cancer Program, London, Ontario (Canada)
  2. Peter MacCallum Cancer Centre, Melbourne (Australia)
Publication Date:
OSTI Identifier:
20951686
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 68; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2006.11.052; PII: S0360-3016(06)03633-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CLINICAL TRIALS; COMPUTERIZED TOMOGRAPHY; IMAGES; PATIENTS; RADIATION DOSES; RADIOTHERAPY; TECHNOLOGY ASSESSMENT

Citation Formats

Bauman, Glenn, Department of Oncology, University of Western Ontario, London, Ontario, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Yartsev, Slav, Rodrigues, George, Department of Oncology, University of Western Ontario, London, Ontario, Department of Biostatistics, University of Western Ontario, London, Ontario, Lewis, Craig, Hammond, Alex, Perera, Francisco, Ash, Robert, Dar, A. Rashid, Department of Oncology, University of Western Ontario, London, Ontario, Venkatesan, Varagur M, Department of Oncology, University of Western Ontario, London, Ontario, Yu, Edward, Lock, Michael, Battista, Jerry, Van Dyk, Jake, Department of Oncology, University of Western Ontario, London, Ontario, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Baily, Laura, Coad, Terry C, Trenka, Kris C, Warr, Barbara, and Kron, Tomas. A Prospective Evaluation of Helical Tomotherapy. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.11.052.
Bauman, Glenn, Department of Oncology, University of Western Ontario, London, Ontario, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Yartsev, Slav, Rodrigues, George, Department of Oncology, University of Western Ontario, London, Ontario, Department of Biostatistics, University of Western Ontario, London, Ontario, Lewis, Craig, Hammond, Alex, Perera, Francisco, Ash, Robert, Dar, A. Rashid, Department of Oncology, University of Western Ontario, London, Ontario, Venkatesan, Varagur M, Department of Oncology, University of Western Ontario, London, Ontario, Yu, Edward, Lock, Michael, Battista, Jerry, Van Dyk, Jake, Department of Oncology, University of Western Ontario, London, Ontario, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Baily, Laura, Coad, Terry C, Trenka, Kris C, Warr, Barbara, & Kron, Tomas. A Prospective Evaluation of Helical Tomotherapy. United States. https://doi.org/10.1016/j.ijrobp.2006.11.052
Bauman, Glenn, Department of Oncology, University of Western Ontario, London, Ontario, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Yartsev, Slav, Rodrigues, George, Department of Oncology, University of Western Ontario, London, Ontario, Department of Biostatistics, University of Western Ontario, London, Ontario, Lewis, Craig, Hammond, Alex, Perera, Francisco, Ash, Robert, Dar, A. Rashid, Department of Oncology, University of Western Ontario, London, Ontario, Venkatesan, Varagur M, Department of Oncology, University of Western Ontario, London, Ontario, Yu, Edward, Lock, Michael, Battista, Jerry, Van Dyk, Jake, Department of Oncology, University of Western Ontario, London, Ontario, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Baily, Laura, Coad, Terry C, Trenka, Kris C, Warr, Barbara, and Kron, Tomas. 2007. "A Prospective Evaluation of Helical Tomotherapy". United States. https://doi.org/10.1016/j.ijrobp.2006.11.052.
@article{osti_20951686,
title = {A Prospective Evaluation of Helical Tomotherapy},
author = {Bauman, Glenn and Department of Oncology, University of Western Ontario, London, Ontario and Department of Medical Biophysics, University of Western Ontario, London, Ontario and Yartsev, Slav and Rodrigues, George and Department of Oncology, University of Western Ontario, London, Ontario and Department of Biostatistics, University of Western Ontario, London, Ontario and Lewis, Craig and Hammond, Alex and Perera, Francisco and Ash, Robert, Dar, A. Rashid and Department of Oncology, University of Western Ontario, London, Ontario and Venkatesan, Varagur M and Department of Oncology, University of Western Ontario, London, Ontario and Yu, Edward and Lock, Michael and Battista, Jerry and Van Dyk, Jake and Department of Oncology, University of Western Ontario, London, Ontario and Department of Medical Biophysics, University of Western Ontario, London, Ontario and Baily, Laura and Coad, Terry C and Trenka, Kris C and Warr, Barbara and Kron, Tomas},
abstractNote = {Purpose: To report results from two clinical trials evaluating helical tomotherapy (HT). Methods and Materials: Patients were enrolled in one of two prospective trials of HT (one for palliative and one for radical treatment). Both an HT plan and a companion three-dimensional conformal radiotherapy (3D-CRT) plan were generated. Pretreatment megavoltage computed tomography was used for daily image guidance. Results: From September 2004 to January 2006, a total of 61 sites in 60 patients were treated. In all but one case, a clinically acceptable tomotherapy plan for treatment was generated. Helical tomotherapy plans were subjectively equivalent or superior to 3D-CRT in 95% of plans. Helical tomotherapy was deemed equivalent or superior in two thirds of dose-volume point comparisons. In cases of inferiority, differences were either clinically insignificant and/or reflected deliberate tradeoffs to optimize the HT plan. Overall imaging and treatment time (median) was 27 min (range, 16-91 min). According to a patient questionnaire, 78% of patients were satisfied to very satisfied with the treatment process. Conclusions: Helical tomotherapy demonstrated clear advantages over conventional 3D-CRT in this diverse patient group. The prospective trials were helpful in deploying this technology in a busy clinical setting.},
doi = {10.1016/j.ijrobp.2006.11.052},
url = {https://www.osti.gov/biblio/20951686}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 68,
place = {United States},
year = {Fri Jun 01 00:00:00 EDT 2007},
month = {Fri Jun 01 00:00:00 EDT 2007}
}