Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation
Abstract
We studied the performance of a dual-panel positron emission tomography (PET) camera dedicated to breast cancer imaging using Monte Carlo simulation. The PET camera under development has two 10x15 cm{sup 2} plates that are constructed from arrays of 1x1x3 mm{sup 3} LSO crystals coupled to novel ultra-thin (<200 {mu}m) silicon position-sensitive avalanche photodiodes (PSAPD). In this design the photodetectors are configured ''edge-on'' with respect to incoming photons which encounter a minimum of 2 cm thick of LSO with directly measured photon interaction depth. Simulations predict that this camera will have 10-15% photon sensitivity, for an 8-4 cm panel separation. Detector measurements show {approx}1 mm{sup 3} intrinsic spatial resolution, <12% energy resolution, and {approx}2 ns coincidence time resolution. By performing simulated dual-panel PET studies using a phantom comprising active breast, heart, and torso tissue, count performance was studied as a function of coincident time and energy windows. We also studied visualization of hot spheres of 2.5-4.0 mm diameter and various locations within the simulated breast tissue for 1x1x3 mm{sup 3}, 2x2x10 mm{sup 3}, 3x3x30 mm{sup 3}, and 4x4x20 mm{sup 3} LSO crystal resolutions and different panel separations. Images were reconstructed by focal plane tomography with attenuation and normalization corrections applied. Simulationmore »
- Authors:
-
- Department of Radiology and Molecular Imaging Program, Stanford University, Stanford, California 94305 (United States)
- Publication Date:
- OSTI Identifier:
- 20951059
- Resource Type:
- Journal Article
- Journal Name:
- Medical Physics
- Additional Journal Information:
- Journal Volume: 34; Journal Issue: 2; Other Information: DOI: 10.1118/1.2409480; (c) 2007 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; CARCINOMAS; COMPUTERIZED SIMULATION; CONCENTRATION RATIO; ENERGY RESOLUTION; GAMMA CAMERAS; HEART; IMAGES; MAMMARY GLANDS; MONTE CARLO METHOD; PHANTOMS; PHOTODETECTORS; PHOTODIODES; POSITRON COMPUTED TOMOGRAPHY; SENSITIVITY; SPATIAL RESOLUTION; TIME RESOLUTION
Citation Formats
Jin, Zhang, Olcott, Peter D, Chinn, Garry, Foudray, Angela M. K., and Levin, Craig S. Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation. United States: N. p., 2007.
Web. doi:10.1118/1.2409480.
Jin, Zhang, Olcott, Peter D, Chinn, Garry, Foudray, Angela M. K., & Levin, Craig S. Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation. United States. https://doi.org/10.1118/1.2409480
Jin, Zhang, Olcott, Peter D, Chinn, Garry, Foudray, Angela M. K., and Levin, Craig S. 2007.
"Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation". United States. https://doi.org/10.1118/1.2409480.
@article{osti_20951059,
title = {Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation},
author = {Jin, Zhang and Olcott, Peter D and Chinn, Garry and Foudray, Angela M. K. and Levin, Craig S},
abstractNote = {We studied the performance of a dual-panel positron emission tomography (PET) camera dedicated to breast cancer imaging using Monte Carlo simulation. The PET camera under development has two 10x15 cm{sup 2} plates that are constructed from arrays of 1x1x3 mm{sup 3} LSO crystals coupled to novel ultra-thin (<200 {mu}m) silicon position-sensitive avalanche photodiodes (PSAPD). In this design the photodetectors are configured ''edge-on'' with respect to incoming photons which encounter a minimum of 2 cm thick of LSO with directly measured photon interaction depth. Simulations predict that this camera will have 10-15% photon sensitivity, for an 8-4 cm panel separation. Detector measurements show {approx}1 mm{sup 3} intrinsic spatial resolution, <12% energy resolution, and {approx}2 ns coincidence time resolution. By performing simulated dual-panel PET studies using a phantom comprising active breast, heart, and torso tissue, count performance was studied as a function of coincident time and energy windows. We also studied visualization of hot spheres of 2.5-4.0 mm diameter and various locations within the simulated breast tissue for 1x1x3 mm{sup 3}, 2x2x10 mm{sup 3}, 3x3x30 mm{sup 3}, and 4x4x20 mm{sup 3} LSO crystal resolutions and different panel separations. Images were reconstructed by focal plane tomography with attenuation and normalization corrections applied. Simulation results indicate that with an activity concentration ratio of tumor:breast:heart:torso of 10:1:10:1 and 30 s of acquisition time, only the dual-plate PET camera comprising 1x1x3 mm{sup 3} crystals could resolve 2.5 mm diameter spheres with an average peak-to-valley ratio of 1.3.},
doi = {10.1118/1.2409480},
url = {https://www.osti.gov/biblio/20951059},
journal = {Medical Physics},
issn = {0094-2405},
number = 2,
volume = 34,
place = {United States},
year = {Thu Feb 15 00:00:00 EST 2007},
month = {Thu Feb 15 00:00:00 EST 2007}
}