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Title: Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer

Abstract

Radiobiological data suggest that prostate cancer has a low {alpha}/{beta} ratio. Large radiotherapy fractions may, therefore, prove more efficacious than standard radiotherapy, while radiotherapy acceleration should further improve control rates. This study describes the radiobiology of a conformal hypofractionated accelerated radiotherapy scheme for the treatment of high risk prostate cancer. Anteroposterior fields to the pelvis deliver a daily dose of 2.7 Gy, while lateral fields confined to the prostate and seminal vesicles deliver an additional daily dose of 0.7 Gy. Radiotherapy is accomplished within 19 days (15 fractions). Dose volume histograms, calculated for tissue specific {alpha}/{beta} ratios and time factors, predict a high biological dose to the prostate and seminal vesicles (77-93 Gy). The biological dose to normal pelvic tissues is maintained at standard levels. Radiobiological dosimetry suggests that, using hypofractionated and accelerated radiotherapy, high biological radiation dose can be given to the prostate without overdosing normal tissues.

Authors:
; ; ;  [1]
  1. Department of Radiotherapy-Oncology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100 (Greece)
Publication Date:
OSTI Identifier:
20853936
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 34; Journal Issue: 1; Other Information: DOI: 10.1118/1.2401655; (c) 2007 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; DOSIMETRY; PELVIS; PROSTATE; RADIATION DOSES; RADIOBIOLOGY; RADIOTHERAPY

Citation Formats

Koukourakis, Michael I, Abatzoglou, Ioannis, Touloupidis, Stavros, Manavis, Ioannis, Department of Urology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, and Department of Radiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100. Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer. United States: N. p., 2007. Web. doi:10.1118/1.2401655.
Koukourakis, Michael I, Abatzoglou, Ioannis, Touloupidis, Stavros, Manavis, Ioannis, Department of Urology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, & Department of Radiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100. Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer. United States. https://doi.org/10.1118/1.2401655
Koukourakis, Michael I, Abatzoglou, Ioannis, Touloupidis, Stavros, Manavis, Ioannis, Department of Urology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, and Department of Radiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100. 2007. "Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer". United States. https://doi.org/10.1118/1.2401655.
@article{osti_20853936,
title = {Biological dose volume histograms during conformal hypofractionated accelerated radiotherapy for prostate cancer},
author = {Koukourakis, Michael I and Abatzoglou, Ioannis and Touloupidis, Stavros and Manavis, Ioannis and Department of Urology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100 and Department of Radiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100},
abstractNote = {Radiobiological data suggest that prostate cancer has a low {alpha}/{beta} ratio. Large radiotherapy fractions may, therefore, prove more efficacious than standard radiotherapy, while radiotherapy acceleration should further improve control rates. This study describes the radiobiology of a conformal hypofractionated accelerated radiotherapy scheme for the treatment of high risk prostate cancer. Anteroposterior fields to the pelvis deliver a daily dose of 2.7 Gy, while lateral fields confined to the prostate and seminal vesicles deliver an additional daily dose of 0.7 Gy. Radiotherapy is accomplished within 19 days (15 fractions). Dose volume histograms, calculated for tissue specific {alpha}/{beta} ratios and time factors, predict a high biological dose to the prostate and seminal vesicles (77-93 Gy). The biological dose to normal pelvic tissues is maintained at standard levels. Radiobiological dosimetry suggests that, using hypofractionated and accelerated radiotherapy, high biological radiation dose can be given to the prostate without overdosing normal tissues.},
doi = {10.1118/1.2401655},
url = {https://www.osti.gov/biblio/20853936}, journal = {Medical Physics},
issn = {0094-2405},
number = 1,
volume = 34,
place = {United States},
year = {Mon Jan 15 00:00:00 EST 2007},
month = {Mon Jan 15 00:00:00 EST 2007}
}