DNA repair systems as targets of cadmium toxicity

Journal Article · Thu Jun 15 00:00:00 EDT 2006 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2006.03.008· OSTI ID:20850350

Giaginis, Constantinos ^[1]; Gatzidou, Elisavet ^[1]; Theocharis, Stamatios ^[1]

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1. Department of Forensic Medicine and Toxicology, University of Athens, Medical School, 75 M. Asias str., Goudi, GR11527 Athens (Greece)

Cadmium (Cd) is a heavy metal and a potent carcinogen implicated in tumor development through occupational and environmental exposure. Recent evidence suggests that proteins participating in the DNA repair systems, especially in excision and mismatch repair, are sensitive targets of Cd toxicity. Cd by interfering and inhibiting these DNA repair processes might contribute to increased risk for tumor formation in humans. In the present review, the information available on the interference of Cd with DNA repair systems and their inhibition is summarized. These actions could possibly explain the indirect contribution of Cd to mutagenic effects and/or carcinogenicity.

• OSTI ID: 20850350
• Journal Information: Toxicology and Applied Pharmacology, Vol. 213, Issue 3; Other Information: DOI: 10.1016/j.taap.2006.03.008; PII: S0041-008X(06)00108-6; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CADMIUM
CARCINOGENS
ENVIRONMENTAL EXPOSURE
EXCISION REPAIR
HEALTH HAZARDS
HEAVY METALS
INHIBITION
INTERFERENCE
NEOPLASMS
NUCLEOTIDES
PROTEINS
REVIEWS
TOXICITY