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Title: Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer

Abstract

Purpose: The aim of this study was to determine the risk factors for late gastrointestinal (GI) morbidity after hypofractionated carbon ion radiotherapy (C-ion RT) for prostate cancer. Methods and Materials: Between April 2000 and November 2003, a Phase II clinical trial of C-ion RT with a total dose of 66 GyE in 20 fractions was performed on 175 patients with prostate cancer, and the correlations of clinical and dosimetric parameters with the incidence of late GI toxicity in 172 patients who survived for more than 18 months were investigated. Results: Although no Grade 3-4 late morbidities of the rectum were observed, Grade 1 and 2 morbidities developed in 23 (13%) and 4 (2%) patients, respectively. Dose-volume histogram analysis revealed that the percentage of rectal volume receiving 50% of the prescribed dose (V50) was significantly higher in patients with rectal toxicity than without toxicity (13.2 {+-} 5.6% with toxicity; 11.4 {+-} 4.0% without toxicity, p = 0.046). Multivariate analysis demonstrated that the use of anticoagulation therapy (p = 0.010) and rectal V50 (p = 0.012) were significant risk factors for the occurrence of Grade 1-2 late GI toxicity. Conclusions: Although C-ion RT with hypofractionation yielded favorable results regarding late GI complication,more » dosimetric parameter was a very important factor in the occurrence of rectal bleeding after C-ion RT as well as photon beam RT. Our results provide useful information for physicians applying charged particle RT in the treatment of prostate cancer.« less

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [2];  [2];  [2];  [1]
  1. Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)
  2. Department of Urology, Graduate School of Medicine, Chiba University, Chiba (Japan)
Publication Date:
OSTI Identifier:
20850224
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 66; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2006.06.056; PII: S0360-3016(06)01180-1; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARBON IONS; CARCINOMAS; CLINICAL TRIALS; CORRELATIONS; DISEASE INCIDENCE; HEALTH HAZARDS; MULTIVARIATE ANALYSIS; PATIENTS; PHOTON BEAMS; PROSTATE; RADIATION DOSES; RADIOTHERAPY; RECTUM; TOXICITY

Citation Formats

Ishikawa, Hitoshi, Tsuji, Hiroshi, Kamada, Tadashi, Hirasawa, Naoki, Yanagi, Takeshi, Mizoe, Jun-Etsu, Akakura, Koichiro, Suzuki, Hiroyoshi, Shimazaki, Jun, and Tsujii, Hirohiko. Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer. United States: N. p., 2006. Web. doi:10.1016/j.ijrobp.2006.06.056.
Ishikawa, Hitoshi, Tsuji, Hiroshi, Kamada, Tadashi, Hirasawa, Naoki, Yanagi, Takeshi, Mizoe, Jun-Etsu, Akakura, Koichiro, Suzuki, Hiroyoshi, Shimazaki, Jun, & Tsujii, Hirohiko. Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer. United States. https://doi.org/10.1016/j.ijrobp.2006.06.056
Ishikawa, Hitoshi, Tsuji, Hiroshi, Kamada, Tadashi, Hirasawa, Naoki, Yanagi, Takeshi, Mizoe, Jun-Etsu, Akakura, Koichiro, Suzuki, Hiroyoshi, Shimazaki, Jun, and Tsujii, Hirohiko. 2006. "Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer". United States. https://doi.org/10.1016/j.ijrobp.2006.06.056.
@article{osti_20850224,
title = {Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer},
author = {Ishikawa, Hitoshi and Tsuji, Hiroshi and Kamada, Tadashi and Hirasawa, Naoki and Yanagi, Takeshi and Mizoe, Jun-Etsu and Akakura, Koichiro and Suzuki, Hiroyoshi and Shimazaki, Jun and Tsujii, Hirohiko},
abstractNote = {Purpose: The aim of this study was to determine the risk factors for late gastrointestinal (GI) morbidity after hypofractionated carbon ion radiotherapy (C-ion RT) for prostate cancer. Methods and Materials: Between April 2000 and November 2003, a Phase II clinical trial of C-ion RT with a total dose of 66 GyE in 20 fractions was performed on 175 patients with prostate cancer, and the correlations of clinical and dosimetric parameters with the incidence of late GI toxicity in 172 patients who survived for more than 18 months were investigated. Results: Although no Grade 3-4 late morbidities of the rectum were observed, Grade 1 and 2 morbidities developed in 23 (13%) and 4 (2%) patients, respectively. Dose-volume histogram analysis revealed that the percentage of rectal volume receiving 50% of the prescribed dose (V50) was significantly higher in patients with rectal toxicity than without toxicity (13.2 {+-} 5.6% with toxicity; 11.4 {+-} 4.0% without toxicity, p = 0.046). Multivariate analysis demonstrated that the use of anticoagulation therapy (p = 0.010) and rectal V50 (p = 0.012) were significant risk factors for the occurrence of Grade 1-2 late GI toxicity. Conclusions: Although C-ion RT with hypofractionation yielded favorable results regarding late GI complication, dosimetric parameter was a very important factor in the occurrence of rectal bleeding after C-ion RT as well as photon beam RT. Our results provide useful information for physicians applying charged particle RT in the treatment of prostate cancer.},
doi = {10.1016/j.ijrobp.2006.06.056},
url = {https://www.osti.gov/biblio/20850224}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 66,
place = {United States},
year = {Wed Nov 15 00:00:00 EST 2006},
month = {Wed Nov 15 00:00:00 EST 2006}
}