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Title: ReVOLT: radiation-enhanced viral oncolytic therapy

Abstract

Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.

Authors:
 [1];  [2];  [3];  [1]
  1. Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL (United States)
  2. Department of Surgery, University of Chicago, Chicago, IL (United States)
  3. Marjorie B. Kovler Viral Oncology Laboratories, University of Chicago, Chicago, IL (United States)
Publication Date:
OSTI Identifier:
20850144
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 66; Journal Issue: 3; Conference: 48. annual meeting of the American Society for Therapeutic Radiology and Oncology, Pennsylvania, PA (United States), 5-9 Nov 2006; Other Information: DOI: 10.1016/j.ijrobp.2006.06.034; PII: S0360-3016(06)01111-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOGENESIS; CLINICAL TRIALS; IONIZING RADIATIONS; MUTANTS; NEOPLASMS; RADIOTHERAPY; TUMOR CELLS; VIRUSES

Citation Formats

Advani, Sunil J, Mezhir, James J, Roizman, Bernard, and Weichselbaum, Ralph R. ReVOLT: radiation-enhanced viral oncolytic therapy. United States: N. p., 2006. Web. doi:10.1016/j.ijrobp.2006.06.034.
Advani, Sunil J, Mezhir, James J, Roizman, Bernard, & Weichselbaum, Ralph R. ReVOLT: radiation-enhanced viral oncolytic therapy. United States. https://doi.org/10.1016/j.ijrobp.2006.06.034
Advani, Sunil J, Mezhir, James J, Roizman, Bernard, and Weichselbaum, Ralph R. 2006. "ReVOLT: radiation-enhanced viral oncolytic therapy". United States. https://doi.org/10.1016/j.ijrobp.2006.06.034.
@article{osti_20850144,
title = {ReVOLT: radiation-enhanced viral oncolytic therapy},
author = {Advani, Sunil J and Mezhir, James J and Roizman, Bernard and Weichselbaum, Ralph R},
abstractNote = {Viral oncolytic therapy has been pursued with renewed interest as the molecular basis of carcinogenesis and viral replication has been elucidated. Genetically engineered, attenuated viruses have been rationally constructed to achieve a therapeutic index in tumor cells compared with surrounding normal tissue. Many of these attenuated mutant viruses have entered clinical trials. Here we review the preclinical literature demonstrating the interaction of oncolytic viruses with ionizing radiation and provides a basis for future clinical trials.},
doi = {10.1016/j.ijrobp.2006.06.034},
url = {https://www.osti.gov/biblio/20850144}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 66,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 2006},
month = {Wed Nov 01 00:00:00 EST 2006}
}