Basic immunology of antibody targeted radiotherapy

Journal Article · Sun Oct 01 00:00:00 EDT 2006 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2005.05.056· OSTI ID:20850087

Wong, Jeffrey Y.C. ^[1]

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1. Division of Radiation Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA (United States)

Antibody targeted radiotherapy brings an important new treatment modality to Radiation oncology clinic. Radiation dose to tumor and normal tissues are determined by a complex interplay of antibody, antigen, tumor, radionuclide, and host-related factors. A basic understanding of these immunologic and physiologic factors is important to optimally utilize this therapy in the clinic. Preclinical and clinical studies need to be continued to broaden our understanding and to develop new strategies to further improve the efficacy of this promising form of targeted therapy.

• OSTI ID: 20850087
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 66, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2005.05.056; PII: S0360-3016(05)01003-5; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
IMMUNOLOGY
NEOPLASMS
RADIATION DOSES
RADIOIMMUNOTHERAPY