A tick B-cell inhibitory protein from salivary glands of the hard tick, Hyalomma asiaticum asiaticum
- Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing, Jiangsu 210095 (China)
- College of Life Sciences, School of Hebei Normal University, Shijiazhuang, Hebei 050016 (China)
- Simcere Pharmaceutical Group, Nanjing, Jiangsu 210092 (China)
Some studies done to date suggest that B-cell inhibitory factor occurred in tick saliva. In this study, a novel protein having B-cell inhibitory activity was purified and characterized from the salivary glands of the hard tick, Hyalomma asiaticum asiaticum. This protein was named B-cell inhibitory factor (BIF). The cDNA encoding BIF was cloned by cDNA library screening. The predicted protein from the cDNA sequence is composed of 138 amino acids including the mature BIF. No similarity was found by Blast search. The lipopolysaccharide-induced B-cell proliferation was inhibited by BIF. This is First report of the identification and characterization of B-cell inhibitory protein from tick. The current study facilitates the study of identifying the interaction among tick, Borrelia burgdorferi, the causative agent of Lyme disease, and host.
- OSTI ID:
- 20798937
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 343, Issue 2; Other Information: DOI: 10.1016/j.bbrc.2006.02.188; PII: S0006-291X(06)00459-1; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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