Cerium and yttrium oxide nanoparticles are neuroprotective

Journal Article · Fri Mar 31 00:00:00 EST 2006 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2006.01.129· OSTI ID:20798867

Schubert, David ^[1]; Dargusch, Richard ^[1]; Raitano, Joan ^[2]; Chan, S -W ^[2]

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1. Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037 (United States)
2. Columbia University, Departments of Applied Physics and Applied Mathematics, 1136 Mudd, MC 4701, New York, NY 10027 (United States)

The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various forms of lethal stress. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. The ceria and yttria nanoparticles act as direct antioxidants to limit the amount of reactive oxygen species required to kill the cells. It follows that this group of nanoparticles could be used to modulate oxidative stress in biological systems.

• OSTI ID: 20798867
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 342, Issue 1; Other Information: DOI: 10.1016/j.bbrc.2006.01.129; PII: S0006-291X(06)00214-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIOXIDANTS
BIOLOGICAL STRESS
CERIUM
CERIUM OXIDES
NANOSTRUCTURES
NERVE CELLS
PARTICLE SIZE
TOXICITY
YTTRIUM OXIDES