Activation of a photosensitive pharmaceutical agent by a triboluminescent material
- Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta T6G 2G8 (Canada)
Given the recent emphasis on applications of triboluminescent materials, we investigate the ability of a triboluminescent material to activate a photosensitive pharmaceutical agent. Using compressed sucrose doped with wintergreen, which luminesces when fractured, we demonstrate the activation of riboflavin (vitamin B2), a photosensitizer. A product of activation is the highly reactive singlet oxygen. We add ascorbic acid (vitamin C), an antioxidant, and measure the amount of ascorbic acid oxidation to correlate with the amount of riboflavin activation. Up to 17% ascorbic acid oxidation is observed, indicating triboluminescence is worth exploring as a mechanism for activation of photosensitizers in photodynamic therapy.
- OSTI ID:
- 20778859
- Journal Information:
- Applied Physics Letters, Vol. 88, Issue 12; Other Information: DOI: 10.1063/1.2189146; (c) 2006 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
- Country of Publication:
- United States
- Language:
- English
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