Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells

Journal Article · Mon May 01 00:00:00 EDT 2006 · Experimental Cell Research

DOI:https://doi.org/10.1016/j.yexcr.2005.12.020· OSTI ID:20775367

Pantano, Serafino ^[1]; Jarrossay, David ^[1]; Saccani, Simona ^[1]; Bosisio, Daniela ^[1]; Natoli, Gioacchino ^[1]

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1. Institute for Research in Biomedicine, Via Vela 6, Bellinzona CH6500 (Switzerland)

Dendritic cell (DC) maturation links peripheral events initiated by the encounter with pathogens to the activation and expansion of antigen-specific T lymphocytes in secondary lymphoid organs. Here, we describe an as yet unrecognized modulator of human DC maturation, the transcriptional repressor BCL6. We found that both myeloid and plasmacytoid DCs constitutively express BCL6, which is rapidly downregulated following maturation triggered by selected stimuli. Both in unstimulated and maturing DCs, control of BCL6 protein levels reflects the convergence of several mechanisms regulating BCL6 stability, mRNA transcription and nuclear export. By regulating the induction of several genes implicated in the immune response, including inflammatory cytokines, chemokines and survival genes, BCL6 may represent a pivotal modulator of the afferent branch of the immune response.

• OSTI ID: 20775367
• Journal Information: Experimental Cell Research, Vol. 312, Issue 8; Other Information: DOI: 10.1016/j.yexcr.2005.12.020; PII: S0014-4827(05)00615-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIGENS
GENES
INFLAMMATION
LYMPHOCYTES
LYMPHOKINES
ORGANS
PATHOGENS
TRANSCRIPTION