Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats
- Department of Food Science and Nutrition, Kyungpook National University, 702-701 Daegu (Korea, Republic of)
- Bionutrigen, Konyang University, 302-911 Chungnam (Korea, Republic of)
- Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, 305-333, Daejon (Korea, Republic of)
- Food and Bio-Industry Research Institute, Kyungpook National University, 702-701, Daegu (Korea, Republic of)
- Department of Genetic Engineering, Kyungpook National University, 702-701, Daegu (Korea, Republic of)
Two amide synthetic derivatives of 3,4-di(OH)-hydrocinnamate (HC), 3,4-dihydroxyphenylpropionic (L-serine methyl ester) amide (E030) and 3,4-dihydroxyphenylpropionic (L-aspartic acid) amide (E076), were investigated to compare their lipid-lowering efficacy with HC. Male rats were fed a 1 g/100 g high-cholesterol diet for 6 weeks with supplements of either clofibrate (0.02%, w/w), HC (0.025%, w/w), E030 (0.039%, w/w) or E076 (0.041%, w/w). The clofibrate supplement was used as a positive control for the lipid-lowering efficacy. The food intakes and body weight gains were not significantly different among the groups. The plasma and hepatic cholesterol and triglyceride levels were lower in clofibrate, HC, E030, and E076-supplemented groups compared to the control group. The supplementation of HC and its amide derivatives was as effective as clofibrate in increasing the ratio of HDL-cholesterol to total plasma cholesterol and reducing the atherogenic index (AI). The hepatic cholesterol level in the HC and E076 groups was significantly lower than that in the clofibrate group. The hepatic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA reductase) and acyl-CoA:cholesterol acyltransferase (ACAT) activities were significantly lower in the all test groups than in the control group. The excretion of neutral sterol was significantly higher in the HC, E030, and E076-supplemented groups compared to the control group. The plasma AST and ALT activities, indirect indexes of hepatic toxicity, were significantly lower in the HC, E030, and E076-supplemented groups than in the control group. Accordingly, the current results suggest that E030 and E076, two amide synthetic derivatives of HC, are effective in lowering lipid activity.
- OSTI ID:
- 20722003
- Journal Information:
- Toxicology and Applied Pharmacology, Vol. 208, Issue 1; Other Information: DOI: 10.1016/j.taap.2005.01.012; PII: S0041-008X(05)00035-9; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
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