The dopamine transporter: role in neurotoxicity and human disease
Journal Article
·
· Toxicology and Applied Pharmacology
- Department of Psychiatry and Behavioral Neuroscience, Pharmacology, and Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201 (United States)
The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD)
- OSTI ID:
- 20721800
- Journal Information:
- Toxicology and Applied Pharmacology, Vol. 204, Issue 3; Other Information: DOI: 10.1016/j.taap.2004.08.013; PII: S0041-008X(04)00407-7; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of the Dopamine Hypothesis of ADHD with PET Brain Imaging
Evaluating Dopamine Reward Pathway in ADHD; clinical implications
The neurotoxicity of amphetamines during the adolescent period
Multimedia
·
Wed Apr 28 00:00:00 EDT 2010
·
OSTI ID:20721800
Evaluating Dopamine Reward Pathway in ADHD; clinical implications
Journal Article
·
Wed Sep 09 00:00:00 EDT 2009
· JAMA, Journal of the American Medical Association
·
OSTI ID:20721800
+10 more
The neurotoxicity of amphetamines during the adolescent period
Journal Article
·
Thu Dec 04 00:00:00 EST 2014
· International Journal of Developmental Neuroscience
·
OSTI ID:20721800
+3 more