Preparation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening
- Department of Physical Electronics, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552 (Japan)
Ferrite nanoparticles (an intermediate between Fe{sub 3}O{sub 4} and {gamma}-Fe{sub 2}O{sub 3}), {approx}7 nm in diameter, were embedded in beads of a mixed polymer of styrene (St) and glycidyl methacrylate (GMA) by emulsifier-free emulsion polymerization method. The beads were coated with GMA by a seeded polymerization method in order to suppress nonspecific protein binding on the surfaces; GMA exhibits very low nonspecific protein binding, which is required for carriers used for bioscreening. The beads have diameters of 180{+-}50 nm and saturation magnetizations of 28 emu/g, exceeding commercially available polymer-coated beads of micron size having a weaker saturation magnetization ({approx}12 emu/g)
- OSTI ID:
- 20711693
- Journal Information:
- Journal of Applied Physics, Vol. 97, Issue 10; Conference: 49. annual conference on magnetism and magnetic materials, Jacksonville, FL (United States), 7-11 Nov 2004; Other Information: DOI: 10.1063/1.1861272; (c) 2005 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
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