Local tumor control after {sup 106}Ru brachytherapy of choroidal melanoma
- Ocular Oncology Service, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool (United Kingdom)
- Department of Physics, Clatterbridge Centre for Oncology, Bebington, Wirral (United Kingdom)
- IC Statistical Services, Wirral (United Kingdom)
- Department of Radiotherapy, Clatterbridge Centre for Oncology, Bebington, Wirral (United Kingdom)
Purpose To report on local tumor control after {sup 106}Ru brachytherapy for choroidal melanoma. Methods and Materials A total of 458 patients with choroidal melanoma were treated at a single institution between January 1993 and December 2001. The tumors had a median longest basal dimension of 10.6 mm and a median height of 3.2 mm. The brachytherapy was administered using a 15- or 20-mm plaque. For posterior tumors, the plaque was positioned eccentrically with its posterior edge aligned with the posterior tumor margin to reduce the radiation dose to the optic disk and fovea. A minimal scleral dose sufficient to cause visible choroidal atrophy provided a permanent ophthalmoscopic record of the distribution of choroidal irradiation. If radiotherapy to the posterior tumor was uncertain, adjunctive transpupillary thermotherapy was administered 6 months postoperatively. Results The actuarial rates of tumor recurrence were 1%, 2%, and 3% at 2, 5, and 7 years, respectively. Local tumor recurrence correlated with the longest basal tumor dimension (Cox univariate analysis, p = 0.02, risk ratio 1.41, 95% confidence interval 1.06-1.88). Seven of the nine eyes with recurrent tumor were salvaged with additional conservative therapy. Conclusion The low rate of local tumor recurrence suggests that ruthenium plaque radiotherapy is effective with good case selection and if special measures are taken to ensure that the plaque is positioned correctly.
- OSTI ID:
- 20702146
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 63, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2005.02.017; PII: S0360-3016(05)00355-X; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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