Predicting and Preventing Skull Overheating in Non Invasive Brain HIFU Treatment Protocols
- Laboratoire Ondes et Acoustique, ESPCI, Universite Paris VII, U.M.R. C.N.R.S. 7587, 10 rue Vauquelin, 75005 Paris (France)
Ultrasound brain therapy is currently limited by the strong phase and amplitude aberrations induced by the heterogeneities of the skull. However the development of aberration correction techniques has made it possible to correct the beam distortion induced by the skull and to produce a sharp focus in the brain. Moreover, using the density of the skull bone that can be obtained with high-resolution CT scans, the corrections needed to produce this sharp focus can be calculated using ultrasound propagation models. We propose here a model for computing the temperature elevation in the skull during High Intensity Focused Ultrasound (HIFU) transcranial therapy. Based on CT scans, the wave propagation through the skull is computed with 3D finite differences wave propagation software. The acoustic simulation is combined with a 3D thermal diffusion code and the temperature elevation inside the skull is computed. Finally, the simulation is validated experimentally by measuring the temperature elevation in several locations of the skull.
- OSTI ID:
- 20630760
- Journal Information:
- AIP Conference Proceedings, Vol. 754, Issue 1; Conference: 4. International symposium on therapeutic ultrasound, Kyoto (Japan), 18-20 Sep 2004; Other Information: DOI: 10.1063/1.1901623; (c) 2005 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
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