Localization of human brain tumors by Tc-99m labelled P-280 synthetic peptide

Journal Article · Sun May 01 00:00:00 EDT 1994 · Journal of Nuclear Medicine

OSTI ID:197975

Muto, P; Varrella, P; Vergara, E ^[1]

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1. Univ. Federico II Napoli (Italy); and others

A preliminary study in humans, using a 3021D molecular weight synthetic peptide (26 amino acids) which includes the RGD sequence that binds to the IIb/IIIa receptor expressed by activated platelets as well as by neoplasm cells, is reported. P-280 labelled with Tc-99M, via a chelator fused to the peptide, allows external gamma imaging. We have studied 21 patients (8 M/ 13 F, 21 to 80 years) with various diseases to define the pharmacokinetic and diagnostic accuracy of this probe. Imaging was performed as follows: dynamic, 0-15 min; planar 0.5, 2 and 4hrs; SPET 3 hrs. p.i. Doses ranged between 17.5-28 mCi of Tc-99m P-280 (0.2-0.4 mg).

• OSTI ID: 197975
• Report Number(s): CONF-940605-; ISSN 0161-5505; TRN: 95:007029-0115
• Journal Information: Journal of Nuclear Medicine, Vol. 35, Issue Suppl.5; Conference: 41. annual meeting of the Society of Nuclear Medicine, Orlando, FL (United States), 5-8 Jun 1994; Other Information: PBD: May 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
NEOPLASMS
ACCURACY
PATIENTS
TECHNETIUM 99