Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q
The protein-tyrosine kinase gene Itk is expressed preferentially in T lymphoid cells of the mouse and is induced by IL-2. A related gene, Btk, is expressed in the murine B lymphoid and myeloid lineages. Because mutations in Btk and the corresponding human gene are associated with X-linked immunodeficiency syndromes, it was of interest to map Itk and its human counterpart. By Southern blot analysis of DNA from the progeny of two multilocus crosses, murine Itk was mapped to chromosome 11. By fluorescence in situ hybridization, human ITK was mapped to 5q32-q33. Murine Itk and its human homologue lie within regions of conserved synteny that includes several growth factor and growth factor receptor genes. This region in humans is frequently deleted in the myelodysplastic syndrome, suggesting possible involvement of ITK in this disorder. 20 refs., 2 figs.
- OSTI ID:
- 186075
- Journal Information:
- Genomics, Vol. 23, Issue 1; Other Information: PBD: 1 Sep 1994
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
HUMAN CHROMOSOME 5
GENETIC MAPPING
TYROSINE
GENES
PHOSPHOTRANSFERASES
GENE MUTATIONS
MICE
HYBRIDIZATION
CHROMOSOMES
PATIENTS
HEREDITARY DISEASES
IMMUNE SYSTEM DISEASES
GROWTH FACTORS
RECEPTORS
BIOLOGICAL MARKERS
NUCLEOTIDES
RFLPS
HUMAN X CHROMOSOME
DNA HYBRIDIZATION
FLUORESCENCE