Potency of 3,3{prime},4,4{prime},5-pentachlorobiphenyl (PCB 126), alone and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), to produce lake trout early life-stage mortality

Journal Article · Fri Dec 01 00:00:00 EST 1995 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1002/etc.5620141222· OSTI ID:162961

Zabel, E W; Peterson, R E ^[1]; Cook, P M ^[2]

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1. Univ. of Wisconsin, Madison, WI (United States)
2. Environmental Protection Agency, Duluth, MN (United States). Environmental Research Lab.

Newly fertilized lake trout (Salvelinus namaycush) eggs were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3{prime},4,4{prime},5-pentachlorobiphenyl (PCB 126), or their combination, and sac fry mortality was used to determine toxic potencies. The toxic equivalency factor (TEF) for PCB 126 was 0.0030. The dose-response curve for the PCB 126/TCDD mixture based on TCDD toxic equivalents was not significantly different from that for TCDD alone, suggesting additivity between the two congeners in causing sac fry mortality.

• Sponsoring Organization: USDOE
• OSTI ID: 162961
• Journal Information: Environmental Toxicology and Chemistry, Vol. 14, Issue 12; Other Information: PBD: Dec 1995
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
POLYCHLORINATED BIPHENYLS
TOXICITY
DIOXIN
TROUT
SENSITIVITY
WATER POLLUTION
AGE DEPENDENCE
DOSE-RESPONSE RELATIONSHIPS