The Serine-rich Domain from Crk-associated Substrate (p130Cas) is a Four-helix Bundle
p130Cas (Crk-associated substrate) is a docking protein that is involved in assembly of focal adhesions and concomitant cellular signaling. It plays a role in physiological regulation of cell adhesion, migration, survival and proliferation, as well as in oncogenic transformation. The molecule consists of multiple protein-protein interaction motifs including a serine-rich region that is positioned between Crk and Src-binding sites. This study reports the first structure of a functional domain of Cas. The solution structure of the serine-rich region has been determined by nuclear magnetic resonance spectroscopy (NMR) demonstrating that this is a stable domain that folds as a four-helix bundle, a protein-interaction motif.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 15020418
- Report Number(s):
- PNNL-SA-45324; JBCHA3; 3993; KP1301030; TRN: US200518%%313
- Journal Information:
- Journal of Biological Chemistry, Vol. 280, Issue 23; ISSN 0021-9258
- Country of Publication:
- United States
- Language:
- English
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