EGF Receptor Sorting in Endosomal Compartments
Signaling through the epidermal growth factor receptor (EGFR) regulates various cellular mechanisms, such as cell growth, survival, proliferation, and differentiation. EGF receptors have an important role in mammalian development and have also been implicated in tumor formation. Although it has been studied for decades, the mechanism by which the EGFR signaling is switched off is poorly understood. Due to limitations in current experimental protocols, identifying the cellular location where the signal is attenuated has proved to be difficult. Computer modeling of the EGFR signaling pathway can complement experimental studies and can potentially help to fill the gaps in our understanding. In the current study, using kinetic simulations, we have investigated how receptor degradation rates in multivesicular endosome compartments affect the spatial distribution and the trafficking dynamics of the EGF receptors. Our results indicate that the variations in the mean lifetime of the late endosomes can have a significant impact on the pool size of the internalized receptors. This could be an important cell type specific regulation mechanism in the EGFR signaling.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 15017453
- Report Number(s):
- PNNL-SA-45021; TRN: US200517%%436
- Resource Relation:
- Conference: Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS '04, June 21-24, 2004, Las Vegas, USA, 451-457; CSREA Press,Bogart,,United States.
- Country of Publication:
- United States
- Language:
- English
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