Diastereoselective synthesis of the major products resulting from the interaction between ionizing radiation and thymidine
Conference
·
OSTI ID:141270
- Colorado State Univ., Fort Collins, CO (United States)
5,6-Dihydro-5,6-dihydroxythymidine (thymidine glycol, 1) and 5,6-dihydro-5-hydroxy-thymidine (C5-thymidine hydrate, 2) are the major products attributed to the effects of {gamma}-radiolysis on thymidine under aerobic and hypoxic conditions, respectively. The authors have achieved the first chemical synthesis of 2 from the respective cis-glycols. Diastereoselective synthesis of 1 and 2 is achieved by carrying out a stereoselective dihydroxylation on the bis-t-butyl-dimethylsilyl ether of thymidine.
- OSTI ID:
- 141270
- Report Number(s):
- CONF-930304-; TRN: 93:003688-0946
- Resource Relation:
- Conference: 205. American Chemical Society national meeting, Denver, CO (United States), 28 Mar - 2 Apr 1993; Other Information: PBD: 1993; Related Information: Is Part Of 205th ACS national meeting; PB: 1951 p.
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:141270