Further evidence of no linkage between schizophrenia and the dopamine D{sub 3} receptor gene locus
- Teikyo Univ. School of Medicine, Tokyo (Japan); and others
The dopamine hypothesis of schizophrenia proposed that dopaminergic pathways are involved in the etiology of the disease. In particular, interest among psychiatrists has focused on the D{sub 2} receptor because of its affinity to antipsychotic drugs. Recently a new dopamine receptor gene has been cloned and named the dopamine D{sub 3} receptor. The D{sub 3} receptor is a potential site for antipsychotic drug action and may be involved in the pathophysiology of schizophrenia. We have carried out a linkage study between the susceptibility gene for schizophrenia and polymorphism of the dopamine D{sub 3} receptor gene in two Japanese pedigrees. The LOD scores were negative for all genetic models and for all affective status at a recombination fraction {theta} = 0. Linkage of DRD{sub 3} has been excluded for the model 1 (dominant model) and the model 3 (recessive model). The LOD score was -3.43 at {theta} = 0 for model 1 (dominant model) and broad definition of affected status. These results were consistent with previous studies. 19 refs., 2 figs., 3 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 135924
- Journal Information:
- American Journal of Medical Genetics, Vol. 54, Issue 3; Other Information: PBD: 15 Sep 1994
- Country of Publication:
- United States
- Language:
- English
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