skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Lack of association between obsessive-compulsive disorder and the dopamine D{sub 3} receptor gene: Some preliminary considerations

Abstract

Controversial results possibly suggesting an association between Tourette`s syndrome (TS) and excess of homozygosity at an Msc I polymorphism in the Dopamine D{sub 3} receptor (DRD{sub 3}) gene have recently been reported. Since a relationship between obsessive-compulsive disorder (OCD) and Tourette`s syndrome (TS) has been suggested, in this study we assessed the frequency of this 2-allele polymorphism in a sample of 97 OCD patients and in 97 control subjects. No statistically significant differences in allele or genotype frequencies were found. Thus this mutation in the coding sequence of the DRD{sub 3} gene is unlikely to confer susceptibility to OCD. 28 refs., 21 tabs.

Authors:
; ;  [1]
  1. Univ. of Milan Medical School (Italy); and others
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
135921
Resource Type:
Journal Article
Journal Name:
American Journal of Medical Genetics
Additional Journal Information:
Journal Volume: 54; Journal Issue: 3; Other Information: PBD: 15 Sep 1994
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; DOPAMINE; RECEPTORS; GENES; GENE MUTATIONS; MUTATION FREQUENCY; PATIENTS; BEHAVIOR; MENTAL DISORDERS; GENOTYPE; STATISTICS; ELECTROPHORESIS; POLYMERASE CHAIN REACTION

Citation Formats

Catalano, M, Sciuto, G, and Di Bella, D. Lack of association between obsessive-compulsive disorder and the dopamine D{sub 3} receptor gene: Some preliminary considerations. United States: N. p., 1994. Web. doi:10.1002/ajmg.1320540312.
Catalano, M, Sciuto, G, & Di Bella, D. Lack of association between obsessive-compulsive disorder and the dopamine D{sub 3} receptor gene: Some preliminary considerations. United States. https://doi.org/10.1002/ajmg.1320540312
Catalano, M, Sciuto, G, and Di Bella, D. 1994. "Lack of association between obsessive-compulsive disorder and the dopamine D{sub 3} receptor gene: Some preliminary considerations". United States. https://doi.org/10.1002/ajmg.1320540312.
@article{osti_135921,
title = {Lack of association between obsessive-compulsive disorder and the dopamine D{sub 3} receptor gene: Some preliminary considerations},
author = {Catalano, M and Sciuto, G and Di Bella, D},
abstractNote = {Controversial results possibly suggesting an association between Tourette`s syndrome (TS) and excess of homozygosity at an Msc I polymorphism in the Dopamine D{sub 3} receptor (DRD{sub 3}) gene have recently been reported. Since a relationship between obsessive-compulsive disorder (OCD) and Tourette`s syndrome (TS) has been suggested, in this study we assessed the frequency of this 2-allele polymorphism in a sample of 97 OCD patients and in 97 control subjects. No statistically significant differences in allele or genotype frequencies were found. Thus this mutation in the coding sequence of the DRD{sub 3} gene is unlikely to confer susceptibility to OCD. 28 refs., 21 tabs.},
doi = {10.1002/ajmg.1320540312},
url = {https://www.osti.gov/biblio/135921}, journal = {American Journal of Medical Genetics},
number = 3,
volume = 54,
place = {United States},
year = {Thu Sep 15 00:00:00 EDT 1994},
month = {Thu Sep 15 00:00:00 EDT 1994}
}