Quantitative relationship between mutagenicity and structure of heterocyclic analogs of pyrene and phenanthrene
- Moscow State Univ. (Russian Federation); and others
In this work, the authors investigated quantitative relationships between mutagenicity and chemical structures of certain heterocyclic analogs of pyrene and phenanthrene that have yet to be examined. Compounds were synthesized using the methods described earlier. The compounds were tested for mutagenic activity by Ames` method. They used the strain Salmonella typhimurium TA1538 (his D3052, rfa, uvr), which registered the reading frame shift mutations. Analysis of the data suggests that the most considerable increases in mutagenicity occur with two nitro groups at positions 2 and 7. When nitro groups occur at other positions, the molecule displayed no mutagenicity, irrespective of the number of groups. Two amino groups at the same position, one amino and one carboxyl group, or chlorine atoms impart a weaker mutagenicity to the molecule. The mutagenic properties were lost on shifting the amino groups from positions 2,7 to 1,6.
- OSTI ID:
- 135580
- Journal Information:
- Doklady Biochemistry, Vol. 339, Issue 1-6; Other Information: PBD: 1994; TN: Translated from Doklady Akademii Nauk; 339: No. 2, 106-108(1994)
- Country of Publication:
- United States
- Language:
- English
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