Rapid and continuous analyte processing in droplet microfluidic devices
The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed.
- Research Organization:
- The Research Foundation for The State University of New York, Albany, NY (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-06ER46323
- Assignee:
- The Research Foundation for The State University of New York
- Patent Number(s):
- 9,625,454
- Application Number:
- 12/875,914
- OSTI ID:
- 1351824
- Resource Relation:
- Patent File Date: 2010 Sep 03
- Country of Publication:
- United States
- Language:
- English
Similar Records
Rapid and continuous magnetic separation in droplet microfluidic devices
Monodisperse alginate microgel formation in a three-dimensional microfluidic droplet generator