Current advances in synchrotron radiation instrumentation for MX experiments

Owen, Robin L.; Juanhuix, Jordi; Fuchs, Martin

doi:10.1016/j.abb.2016.03.021

Title: Current advances in synchrotron radiation instrumentation for MX experiments

Journal Article · Fri Apr 01 00:00:00 EDT 2016 · Archives of Biochemistry and Biophysics

DOI:https://doi.org/10.1016/j.abb.2016.03.021· OSTI ID:1349554

Owen, Robin L. ^[1];

^[2]; Fuchs, Martin ^[3]

Harwell Science and Innovation Campus, Didcot (United Kingdom)
Alba Sychrotron, Cerdanyola (Spain)
Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II

Following pioneering work 40 years ago, synchrotron beamlines dedicated to macromolecular crystallography (MX) have improved in almost every aspect as instrumentation has evolved. Beam sizes and crystal dimensions are now on the single micron scale while data can be collected from proteins with molecular weights over 10 MDa and from crystals with unit cell dimensions over 1000 Å. Moreover, it is possible to collect a complete data set in seconds, and obtain the resulting structure in minutes. The impact of MX synchrotron beamlines and their evolution is reflected in their scientific output, and MX is now the method of choice for a variety of aims from ligand binding to structure determination of membrane proteins, viruses and ribosomes, resulting in a much deeper understanding of the machinery of life. One main driving force of beamline evolution have been advances in almost every aspect of the instrumentation comprising a synchrotron beamline. In this review we aim to provide an overview of the current status of instrumentation at modern MX experiments. Furthermore, we discuss the most critical optical components, aspects of endstation design, sample delivery, visualisation and positioning, the sample environment, beam shaping, detectors and data acquisition and processing.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC00112704

OSTI ID:: 1349554

Report Number(s):: BNL-112616-2016-JA

Journal Information:: Archives of Biochemistry and Biophysics, Vol. 602, Issue C; ISSN 0003-9861

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 42 works

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Fragments: where are we now? Osborne, James; Panova, Stanislava; Rapti, Magdalini Biochemical Society Transactions, Vol. 48, Issue 1 https://doi.org/10.1042/bst20190694	journal	January 2020
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A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography de Wijn, Raphaël; Hennig, Oliver; Roche, Jennifer International Union of Crystallography (IUCr) https://doi.org/10.1107/s2052252519003622/lz5024sup1.pdf	text	January 2019
Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II Miller, Michelle; Maheshwari, Sweta; Shi, Wuxian Molecules, Vol. 24, Issue 3 https://doi.org/10.3390/molecules24030496	journal	January 2019

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