Linkage disequilibria between polymorphisms of the apolipoprotein B gene signal peptide Ag(al/d) and Ag(c/g) in the Singapore Chinese
- National Univ. of Singapore (Malaysia)
Three polymorphisms [insertion/deletion polymorphisms of signal peptides (ins/del), Ag(al/d) and Ag(c/g)] were studied in one hundred and ninety-five healthy Singaporean Chinese of both sexes. The respective regions of the apoB gene were amplified by polymerase chain reactions. The amplified products of Ag(al/d) and Ag(c/g) were digested by restriction enzymes AluI and ApaLI, respectively. Their DNA fragments were subsequently separated and visualized on a 2% agarose gel. Ins/del polymorphism could be typed directly on 4% agarose gel without any digestion. Computation of the chi-square and delta value revealed linkage disequilibria between ins/del and Ag(c/g) [{chi}{sup 2}=43.24, {triangle}=0.31, P<0.00001], ins/del and Ag(al/d) [{chi}{sup 2}=22.28, {triangle}=0.32, P<0.001], Ag(c/g) and Ag(al/d) [{chi}{sup 2}=106.01, {triangle}=0.63, P<0.00001].
- OSTI ID:
- 134657
- Report Number(s):
- CONF-941009-; ISSN 0002-9297; TRN: 95:005313-1394
- Journal Information:
- American Journal of Human Genetics, Vol. 55, Issue Suppl.3; Conference: 44. annual meeting of the American Society of Human Genetics, Montreal (Canada), 18-22 Oct 1994; Other Information: PBD: Sep 1994
- Country of Publication:
- United States
- Language:
- English
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