Multiscale polar theory of microtubule and motor-protein assemblies

Gao, Tong; Blackwell, Robert; Glaser, Matthew A.; Betterton, Meredith D.; Shelley, Michael J.

doi:10.1103/PhysRevLett.114.048101

Title: Multiscale polar theory of microtubule and motor-protein assemblies

Journal Article · Tue Jan 27 00:00:00 EST 2015 · Physical Review Letters

DOI:https://doi.org/10.1103/PhysRevLett.114.048101· OSTI ID:1343759

Gao, Tong ^[1]; Blackwell, Robert ^[2]; Glaser, Matthew A. ^[2]; Betterton, Meredith D. ^[2]; Shelley, Michael J. ^[1]

New York Univ. (NYU), New York, NY (United States)
Univ. of Colorado, Boulder, CO (United States)

Microtubules and motor proteins are building blocks of self-organized subcellular biological structures such as the mitotic spindle and the centrosomal microtubule array. These same ingredients can form new “bioactive” liquid-crystalline fluids that are intrinsically out of equilibrium and which display complex flows and defect dynamics. It is not yet well understood how microscopic activity, which involves polarity-dependent interactions between motor proteins and microtubules, yields such larger-scale dynamical structures. In our multiscale theory, Brownian dynamics simulations of polar microtubule ensembles driven by cross-linking motors allow us to study microscopic organization and stresses. Polarity sorting and cross-link relaxation emerge as two polar-specific sources of active destabilizing stress. On larger length scales, our continuum Doi-Onsager theory captures the hydrodynamic flows generated by polarity-dependent active stresses. Finally, the results connect local polar structure to flow structures and defect dynamics.

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Research Organization:: New York Univ. (NYU), NY (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: FG02-88ER25053

OSTI ID:: 1343759

Alternate ID(s):: OSTI ID: 1180164

Journal Information:: Physical Review Letters, Vol. 114, Issue 4; ISSN 0031-9007

Publisher:: American Physical Society (APS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 105 works

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