Overexpression of RAR{beta}4 and p53 in murine lung cancer
- Universite de Montreal (Canada)
Lung cancer is the leading cause of cancer death in western societies. There are four major histological types: small cell, epidemoid carcinoma, adenocarcinoma and large cell carcinoma, the adenocarcinoma being the only type generally found in the mouse. Earlier studies have shown that the transgenes coding for isoform 4 of the retinoic acid receptor {beta} and a mutant form of the tumor suppressor p53 are involved in the development of lung cancer. These results led us to ask whether the two genes may contribute to lung carcinogenesis in a synergistic manner. Mice overexpressing a RAR{beta}4-like isoform transgene (which causes very marked hyperplasia of alveolar type II cells) and mutated p53 transgene were crossed and progeny were analyzed after treatment with the lung carcinogen urethane. The results to date suggest that in the double transgenic mice, lung tumor kinetics do not result from cooperation between those transgenes since the effect of the transgenes was additive rather than synergistic. We conclude that RAR{beta}4 and p53 are involved in different tumorigenic pathways.
- OSTI ID:
- 133533
- Report Number(s):
- CONF-941009-; ISSN 0002-9297; TRN: 95:005313-0261
- Journal Information:
- American Journal of Human Genetics, Vol. 55, Issue Suppl.3; Conference: 44. annual meeting of the American Society of Human Genetics, Montreal (Canada), 18-22 Oct 1994; Other Information: PBD: Sep 1994
- Country of Publication:
- United States
- Language:
- English
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