Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds

Ailianou, Artemis; Ramachandran, Karthik; Kossuth, Mary Beth; Oberhauser, James Paul; Kornfield, Julia A.

doi:10.1073/pnas.1602311113

Title: Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds

Journal Article · Mon Sep 26 00:00:00 EDT 2016 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1602311113· OSTI ID:1331703

Ailianou, Artemis ^[1]; Ramachandran, Karthik ^[1]; Kossuth, Mary Beth ^[2]; Oberhauser, James Paul ^[2]; Kornfield, Julia A. ^[1]

California Inst. of Technology (CalTech), Pasadena, CA (United States)
Abbott Vascular, Santa Clara, CA (United States)

Poly(L-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery. We used X-ray microdiffraction to discover how PLLA acquired ductile character and found that the crimping process creates localized regions of extreme anisotropy; PLLA chains in the scaffold change orientation from the hoop direction to the radial direction on micrometer-scale distances. This multiplicity of morphologies in the crimped scaffold works in tandem to enable a low-stress response during deployment, which avoids fracture of the PLLA hoops and leaves them with the strength needed to support the artery. Furthermore, the transformations of the semicrystalline PLLA microstructure during crimping explain the unexpected strength and ductility of the current BVS and point the way to thinner resorbable scaffolds in the future.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division

Grant/Contract Number:: AC02-06CH11357; AC02-05CH1123

OSTI ID:: 1331703

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 42; ISSN 0027-8424

Publisher:: National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 32 works

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59 BASIC BIOLOGICAL SCIENCES
structural transformation
ductility
poly (l-lactide)
coronary heart disease
microdiffraction

Title: Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds

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