While-you-wait proteins? Producing biomolecules at the point of need

Mohr, Benjamin P.; Retterer, Scott T.; Doktycz, Mitchel J.

doi:10.1080/14789450.2016.1209415

Title: While-you-wait proteins? Producing biomolecules at the point of need

Journal Article · Tue Jul 12 00:00:00 EDT 2016 · Expert Review of Proteomics

DOI:https://doi.org/10.1080/14789450.2016.1209415· OSTI ID:1327609

Mohr, Benjamin P. ^[1]; Retterer, Scott T. ^[2]; Doktycz, Mitchel J. ^[2]

Univ. of Tennessee, Knoxville, TN (United States). Bresden Center for Interdisciplinary Research; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
Univ. of Tennessee, Knoxville, TN (United States). Bresden Center for Interdisciplinary Research; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division and Center for Nanophase and Material Sciences

Potency and specificity have made protein drugs, or biologics, popular for the pharmaceutical industry due to their unparalleled potency and specificity. Due to their temperature sensitivity, however, storage and distribution remain challenges. Furthermore, industrial scale production of biologics is not well matched to the needs of personalized medicine. To take full advantage of the potential of biologics, new methodologies for their synthesis and purification are required to produce them when and where they are needed most at the point of care. Cell-free protein synthesis possesses the requisite portability and versatility to meet these needs. Some recent innovations that lead to distributed production techniques, enhanced product yields, and custom modifications will enable the rapid, on-demand production of personalized medicines.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

DOE Contract Number:: AC05-00OR22725

OSTI ID:: 1327609

Journal Information:: Expert Review of Proteomics, Vol. 13, Issue 8; ISSN 1478-9450

Publisher:: Taylor & Francis

Country of Publication:: United States

Language:: English

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