Succinic acid production from lignocellulosic hydrolysate by Basfia succiniciproducens

Salvachúa, Davinia; Smith, Holly; St. John, Peter C.; Mohagheghi, Ali; Peterson, Darren J.; Black, Brenna A.; Dowe, Nancy; Beckham, Gregg T.

doi:10.1016/j.biortech.2016.05.018

Title: Succinic acid production from lignocellulosic hydrolysate by Basfia succiniciproducens

Journal Article · Mon May 09 00:00:00 EDT 2016 · Bioresource Technology

DOI:https://doi.org/10.1016/j.biortech.2016.05.018· OSTI ID:1254113

Salvachúa, Davinia ^[1]; Smith, Holly ^[1]; St. John, Peter C. ^[1]; Mohagheghi, Ali ^[1]; Peterson, Darren J. ^[1]; Black, Brenna A. ^[1]; Dowe, Nancy ^[1]; Beckham, Gregg T. ^[1]

National Renewable Energy Lab. (NREL), Golden, CO (United States). National Bioenergy Center

The production of chemicals alongside fuels will be essential to enhance the feasibility of lignocellulosic biorefineries. Succinic acid (SA), a naturally occurring C4-diacid, is a primary intermediate of the tricarboxylic acid cycle and a promising building block chemical that has received significant industrial attention. Basfia succiniciproducens is a relatively unexplored SA-producing bacterium with advantageous features such as broad substrate utilization, genetic tractability, and facultative anaerobic metabolism. Here B. succiniciproducens is evaluated in high xylose-content hydrolysates from corn stover and different synthetic media in batch fermentation. SA titers in hydrolysate at an initial sugar concentration of 60 g/L reached up to 30 g/L, with metabolic yields of 0.69 g/g, and an overall productivity of 0.43 g/L/h. These results demonstrate that B. succiniciproducens may be an attractive platform organism for bio-SA production from biomass hydrolysates.

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Research Organization:: National Renewable Energy Laboratory (NREL), Golden, CO (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Sustainable Transportation Office. Bioenergy Technologies Office (BETO)

Grant/Contract Number:: AC36-08GO28308

OSTI ID:: 1254113

Alternate ID(s):: OSTI ID: 1326455

Report Number(s):: NREL/JA-5100-66481

Journal Information:: Bioresource Technology, Vol. 214, Issue C; ISSN 0960-8524

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 52 works

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Biotechnological route for sustainable succinate production utilizing oil palm frond and kenaf as potential carbon sources Luthfi, Abdullah Amru Indera; Manaf, Shareena Fairuz Abdul; Illias, Rosli Md Applied Microbiology and Biotechnology, Vol. 101, Issue 8 https://doi.org/10.1007/s00253-017-8210-z	journal	March 2017
Bio-Based Succinate Production from Arundo donax Hydrolysate with the New Natural Succinic Acid-Producing Strain Basfia succiniciproducens BPP7 Ventorino, Valeria; Robertiello, Alessandro; Cimini, Donatella BioEnergy Research, Vol. 10, Issue 2 https://doi.org/10.1007/s12155-017-9814-y	journal	January 2017
Metabolic engineering of Corynebacterium glutamicum for efficient production of succinate from lignocellulosic hydrolysate Mao, Yufeng; Li, Guiying; Chang, Zhishuai Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1094-z	journal	April 2018
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09 BIOMASS FUELS
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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Title: Succinic acid production from lignocellulosic hydrolysate by Basfia succiniciproducens

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