Peptides having reduced toxicity that stimulate cholesterol efflux

Bielicki, John K.; Johansson, Jan; Danho, Waleed

Title: Peptides having reduced toxicity that stimulate cholesterol efflux

Patent · Tue Aug 16 00:00:00 EDT 2016

OSTI ID:1298004

Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,416,162

Application Number:: 14/216,749

OSTI ID:: 1298004

Resource Relation:: Patent File Date: 2014 Mar 17

Country of Publication:: United States

Language:: English

References (20)

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