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Title: Design and biocompatibility of endovascular aneurysm filling devices

We report that the rupture of an intracranial aneurysm, which can result in severe mental disabilities or death, affects approximately 30,000 people in the United States annually. The traditional surgical method of treating these arterial malformations involves a full craniotomy procedure, wherein a clip is placed around the aneurysm neck. In recent decades, research and device development have focused on new endovascular treatment methods to occlude the aneurysm void space. These methods, some of which are currently in clinical use, utilize metal, polymeric, or hybrid devices delivered via catheter to the aneurysm site. In this review, we present several such devices, including those that have been approved for clinical use, and some that are currently in development. We present several design requirements for a successful aneurysm filling device and discuss the success or failure of current and past technologies. Lastly, we also present novel polymeric based aneurysm filling methods that are currently being tested in animal models that could result in superior healing.
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [3]
  1. Texas A&M Univ., College Station, TX (United States). Dept. of Biomedical Engineering
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Chemical Sciences Division
  3. Department of Biomedical Engineering, Texas A&M University, 3120 TAMU College Station Texas 77843
Publication Date:
OSTI Identifier:
Grant/Contract Number:
AC52-07NA27344; R01EB000462
Accepted Manuscript
Journal Name:
Journal of Biomedical Materials Research. Part A
Additional Journal Information:
Journal Volume: 103; Journal Issue: 4; Journal ID: ISSN 1549-3296
Research Org:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE; National Inst. of Health (NIH)
Country of Publication:
United States
60 APPLIED LIFE SCIENCES; 47 OTHER INSTRUMENTATION intracranial aneurysm; shape memory polymer; aneurysm filling device; endovascular; embolization