Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates

Xia, Yan; Li, Ming; Charubin, Kamil; Liu, Ying; Heberle, Frederick A.; Katsaras, John; Jing, Benxin; Zhu, Yingxi; Nieh, Mu-Ping

doi:10.1021/acs.langmuir.5b03291

Title: Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates

Journal Article · Thu Nov 05 00:00:00 EST 2015 · Langmuir

DOI:https://doi.org/10.1021/acs.langmuir.5b03291· OSTI ID:1265607

Xia, Yan ^[1]; Li, Ming ^[2]; Charubin, Kamil ^[1]; Liu, Ying ^[1]; Heberle, Frederick A. ^[3]; Katsaras, John ^[4]; Jing, Benxin ^[5]; Zhu, Yingxi ^[6]; Nieh, Mu-Ping ^[7]

Univ. of Connecticut, Storrs, CT (United States). Dept. of Chemical and Biomolecular Engineering
Univ. of Connecticut, Storrs, CT (United States). Inst. of Materials Science. Polymer Program
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics and Astronomy; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences
Univ. of Notre Dame, IN (United States). Dept. of Chemical and Biomolecular Engineering
Univ. of Notre Dame, IN (United States). Dept. of Chemical and Biomolecular Engineering; Wayne State Univ., Detroit, MI (United States). Dept. of Chemical Engineering and Materials Science
Univ. of Connecticut, Storrs, CT (United States). Dept. of Chemical and Biomolecular Engineering; Univ. of Connecticut, Storrs, CT (United States). Inst. of Materials Science. Polymer Program; Univ. of Connecticut, Storrs, CT (United States). Dept. of Biomedical Engineering

In this paper, we report on studies of lipid transfer rates between different morphology nanoparticles and lipids with different length acyl chains. The lipid transfer rate of dimyristoylphosphatidylcholine (di-C₁₄, DMPC) in discoidal “bicelles” (0.156 h^–1) is 2 orders of magnitude greater than that of DMPC vesicles (ULVs) (1.1 × 10^–3 h^–1). For both bicellar and ULV morphologies, increasing the acyl chain length by two carbons [going from di-C₁₄ DMPC to di-C₁₆, dipalmitoylphosphatidylcholine (DPPC)] causes lipid transfer rates to decrease by more than 2 orders of magnitude. Results from small angle neutron scattering (SANS), differential scanning calorimetry (DSC), and fluorescence correlation spectroscopy (FCS) are in good agreement. Finally, the present studies highlight the importance of lipid dynamic processes taking place in different morphology biomimetic membranes.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). National Science Foundation (NSF) (United States)

Contributing Organization:: Univ. of Connecticut, Storrs, CT (United States); Univ. of Notre Dame, IN (United States)

Grant/Contract Number:: AC05-00OR22725; FG02-07ER46390; NSF-CMMI 1131587; CBET 1433903

OSTI ID:: 1265607

Journal Information:: Langmuir, Vol. 31, Issue 47; ISSN 0743-7463

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 21 works

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