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Title: ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

Abstract

Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular focus on fluorine-18 (18F). The key to the system is the combination of a radiation detector measuring radioactivity concentration, in line with a peristaltic pump dispensing known volumes. Results show the combined system demonstrates volume variation to be within 5 % for dispensing volumes of 20 μL or greater. When considering volumes of 20 μL or greater, the delivered radioactivity is in agreement with the requested amount as measured independently with a dose calibrator to within 2 % on average. In conclusion, the integration of the detector and pump in an in-line system leads to a flexible and compact approach that can accurately dispense solutions containing radioactivity concentrations ranging from the high values typical of [18F]fluoride directly produced from a cyclotron (~0.1-1 mCi μL-1) to the low values typical of batches of [18F]fluoride-labeled radiotracers intended for preclinical mouse scans (~1-10 μCi μL-1).

Authors:
; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI Identifier:
1619333
Alternate Identifier(s):
OSTI ID: 1259519
Grant/Contract Number:  
SC0001249; R25T CA098010
Resource Type:
Journal Article: Published Article
Journal Name:
EJNMMI Research
Additional Journal Information:
Journal Name: EJNMMI Research Journal Volume: 6 Journal Issue: 1; Journal ID: ISSN 2191-219X
Publisher:
Springer Science + Business Media
Country of Publication:
Germany
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Dooraghi, Alex A., Carroll, Lewis, Collins, Jeffrey, van Dam, R. Michael, and Chatziioannou, Arion F. ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes. Germany: N. p., 2016. Web. doi:10.1186/s13550-016-0176-9.
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Dooraghi, Alex A., Carroll, Lewis, Collins, Jeffrey, van Dam, R. Michael, & Chatziioannou, Arion F. ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes. Germany. https://doi.org/10.1186/s13550-016-0176-9
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Dooraghi, Alex A., Carroll, Lewis, Collins, Jeffrey, van Dam, R. Michael, and Chatziioannou, Arion F. 2016. "ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes". Germany. https://doi.org/10.1186/s13550-016-0176-9.
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@article{osti_1619333,
title = {ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes},
author = {Dooraghi, Alex A. and Carroll, Lewis and Collins, Jeffrey and van Dam, R. Michael and Chatziioannou, Arion F.},
abstractNote = {Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular focus on fluorine-18 (18F). The key to the system is the combination of a radiation detector measuring radioactivity concentration, in line with a peristaltic pump dispensing known volumes. Results show the combined system demonstrates volume variation to be within 5 % for dispensing volumes of 20 μL or greater. When considering volumes of 20 μL or greater, the delivered radioactivity is in agreement with the requested amount as measured independently with a dose calibrator to within 2 % on average. In conclusion, the integration of the detector and pump in an in-line system leads to a flexible and compact approach that can accurately dispense solutions containing radioactivity concentrations ranging from the high values typical of [18F]fluoride directly produced from a cyclotron (~0.1-1 mCi μL-1) to the low values typical of batches of [18F]fluoride-labeled radiotracers intended for preclinical mouse scans (~1-10 μCi μL-1).},
doi = {10.1186/s13550-016-0176-9},
url = {https://www.osti.gov/biblio/1619333}, journal = {EJNMMI Research},
issn = {2191-219X},
number = 1,
volume = 6,
place = {Germany},
year = {Wed Mar 09 00:00:00 EST 2016},
month = {Wed Mar 09 00:00:00 EST 2016}
}
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Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at https://doi.org/10.1186/s13550-016-0176-9
Copyright Statement
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Cited by: 4 works
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Works referenced in this record:

Multimodality Rodent Imaging Chambers for Use Under Barrier Conditions with Gas Anesthesia
journal, August 2008

Extremity doses of nuclear medicine personnel: a concern
journal, November 2011

Validation of a new protocol for 18F-FDG infusion using an automatic combined dispenser and injector system
journal, June 2012

A semi-automated vascular access system for preclinical models
journal, July 2013

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