skip to main content

SciTech ConnectSciTech Connect

Title: Restricted mobility of specific functional groups reduces anti-cancer drug activity in healthy cells

Here, the most common cancer treatments currently available are radio- and chemo-therapy. These therapies have, however, drawbacks, such as, the reduction in quality of life and the low efficiency of radiotherapy in cases of multiple metastases. To lessen these effects, we have encapsulated an anti-cancer drug into a biocompatible matrix. In-vitro assays indicate that this bio-nanocomposite is able to interact and cause morphological changes in cancer cells. Meanwhile, no alterations were observed in monocytes and fibroblasts, indicating that this system might carry the drug in living organisms with reduced clearance rate and toxicity. X-rays and neutrons were used to investigate the carrier structure, as well as to assess the drug mobility within the bio-nanocomposite. In conclusion, from these unique data we show that partial mobility restriction of active groups of the drug molecule suggests why this carrier design is potentially safer to healthy cells.
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [5] ;  [6] ;  [5] ;  [7]
  1. Univ. of Copenhagen, Copenhagen (Denmark); Univ. Estadual Paulista (Brazil)
  2. Univ. of Copenhagen, Copenhagen (Denmark)
  3. Univ. of South Florida, Tampa, FL (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  4. Paul Scherrer Inst. (PSI), Villigen (Switzerland)
  5. Univ. Estadual Paulista (Brazil)
  6. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  7. Univ. of Copenhagen, Copenhagen (Denmark); European Spallation Source ESS AB, Lund (Sweden)
Publication Date:
OSTI Identifier:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 6; Journal ID: ISSN 2045-2322
Nature Publishing Group
Research Org:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
59 BASIC BIOLOGICAL SCIENCES cancer therapy; nanoparticles