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Title: Development of the Plutonium-DTPA biokinetic model

Estimating radionuclide intakes from bioassays following chelation treatment presents a challenge to the dosimetrist due to the observed excretion enhancement of the particular radionuclide of concern, where no standard biokinetic model exists. This document provides a Pu-DTPA biokinetic model that may be used for making such determination for plutonium intakes. The Pu-DTPA biokinetic model is intended to supplement the standard recommended biokinetic models. The model was used to evaluate several chelation strategies that resulted in providing recommendations for effective treatment. These recommendations supported early treatment for soluble particle inhalations and an initial 3-day treatment series of DTPA treatments for wounds. Several late chelation strategies were also compared where reduced treatment frequencies proved to be as effective as multiple treatments. Furthermore, the Pu-DTPA biokinetic model can be used to assist in estimating initial intakes of transuranic radionuclides, and for studying the effects of different treatment strategies.
 [1] ;  [2]
  1. CH2-WG Idaho, LLC, Idaho Falls, ID (United States)
  2. Idaho State Univ., Pocatello, ID (United States)
Publication Date:
OSTI Identifier:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 108; Journal Issue: 6; Related Information: (Provide citations for supplementary items published with journal articles, or any other citation directly supporting the document you are submitting. Or, see the Related DOIs field below.); Journal ID: ISSN 0017-9078
Health Physics Society
Research Org:
CH2-WG Idaho, LLC, Idaho Falls, ID (United States)
Sponsoring Org:
USDOE Office of Environmental Management (EM)
Contributing Orgs:
Enter names of organizations that provided significant assistance but not direct funding
Country of Publication:
United States
61 RADIATION PROTECTION AND DOSIMETRY DTPA; Plutonium; Chelation; Biokinetics