The Stanford Automated Mounter: Pushing the limits of sample exchange at the SSRL macromolecular crystallography beamlines

Russi, Silvia; Song, Jinhu; McPhillips, Scott E.; Cohen, Aina E.

doi:10.1107/S1600576716000649

Title: The Stanford Automated Mounter: Pushing the limits of sample exchange at the SSRL macromolecular crystallography beamlines

Journal Article · Wed Feb 24 00:00:00 EST 2016 · Journal of Applied Crystallography (Online)

DOI:https://doi.org/10.1107/S1600576716000649· OSTI ID:1253923

Russi, Silvia ^[1]; Song, Jinhu ^[1]; McPhillips, Scott E. ^[1]; Cohen, Aina E. ^[1]

SLAC National Accelerator Lab., Menlo Park, CA (United States)

The Stanford Automated Mounter System, a system for mounting and dismounting cryo-cooled crystals, has been upgraded to increase the throughput of samples on the macromolecular crystallography beamlines at the Stanford Synchrotron Radiation Lightsource. This upgrade speeds up robot maneuvers, reduces the heating/drying cycles, pre-fetches samples and adds an air-knife to remove frost from the gripper arms. As a result, sample pin exchange during automated crystal quality screening now takes about 25 s, five times faster than before this upgrade.

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Research Organization:: SLAC National Accelerator Lab., Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 1253923

Report Number(s):: SLAC-PUB-16477; JACGAR; PII: S1600576716000649

Journal Information:: Journal of Applied Crystallography (Online), Vol. 49, Issue 2; ISSN 1600-5767

Publisher:: International Union of CrystallographyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 22 works

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References (11)

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Biochemical and structural characterization of two variants of uncertain significance in the PMS2 gene D'Arcy, Brandon M.; Blount, Jessa; Prakash, Aishwarya Human Mutation, Vol. 40, Issue 4 https://doi.org/10.1002/humu.23708	journal	January 2019
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death Houl, Jerry H.; Ye, Zu; Brosey, Chris A. Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-13508-4	journal	December 2019
Structural basis of broad ebolavirus neutralization by a human survivor antibody West, Brandyn R.; Wec, Anna Z.; Moyer, Crystal L. Nature Structural & Molecular Biology, Vol. 26, Issue 3 https://doi.org/10.1038/s41594-019-0191-4	journal	March 2019
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Strategies for sample delivery for femtosecond crystallography Martiel, Isabelle; Müller-Werkmeister, Henrike M.; Cohen, Aina E. International Union of Crystallography (IUCr) https://doi.org/10.1107/s2059798318017953/ba5296sup1.pdf	text	January 2019

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automated crystal mounting
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sample exchange robot
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cryo-crystallography

Title: The Stanford Automated Mounter: Pushing the limits of sample exchange at the SSRL macromolecular crystallography beamlines

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